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关于中风后认知的发展轨迹的纵向研究:基于基于小组的轨迹模型
Yuxia Ma1, Qiuxia Qian1, Tingting Yang1
1Evidence-Based Nursing Center, School of Nursing, Lanzhou University, Lanzhou, Gansu, China.
Neurological research
|February 8, 2026
概括
脑卒中后的认知遵循不同的轨迹,通过基于组的建模来确定. 了解这些独特的认知路径有助于针对性干预中风幸存者.
科学领域:
- 神经学 神经学
- 认知科学 认知科学
- 公共卫生 公共卫生
背景情况:
- 卒中是导致长期残疾的主要原因,通常导致认知障碍.
- 了解中风后认知恢复的异质性对于有效的患者管理至关重要.
- 以前的研究还没有完全阐明中风后认知变化的动态轨迹.
研究的目的:
- 为了确定脑卒中后认知的不同发展轨迹.
- 探索影响中风患者认知发展的因素.
- 应用基于小组的轨迹模型来分析随时间推移的认知变化.
主要方法:
- 一项纵向队列研究,涉及1060名中风患者.
- 从2021年9月到2023年2月收集的数据,随访时间为1,3个月和6个月.
- 迷你心理状态检查 (MMSE) 的得分被用来建模认知轨迹.
主要成果:
- 确定了四种不同的认知发展轨迹:持续严重的中风后认知障碍 (PSCI),持续轻度的PSCI,PSCI风险组和正常的认知组.
- 共有655名患者完成了后续评估.
- 基于组的轨迹模型成功地根据MMSE变化区分了这些子组.
结论:
- 脑卒中后的认知发展轨迹表现出显著的异质性.
- 识别这些不同的轨迹对于识别有风险的人群至关重要.
- 根据特定的认知轨迹进行量身定制的监测和干预可以改善中风幸存者的结果.
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