麻症和高风险非肌肉侵入性膀癌的复发风险:非线性建模方法
Gerald Klinglmair1, Maximilian Lutz2, Tatia Telia2
1Department of Urology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria.
The journal of nutrition, health & aging
|February 8, 2026
概括
身体组成,包括体重指数 (BMI),骨肌肉指数 (SMI) 和psoas肌肉指数 (PMI),显示高风险的非肌肉侵入性膀癌 (NMIBC) 患者与复发风险的非线性关联,这些患者接受了Bacillus Calmette-Guérin (BCG) 治疗. 低和过度的身体和肌肉质量都可能对疾病控制产生负面影响.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 老年病的医生 老年病的医生
背景情况:
- 在许多癌症中,人们都知道肉症和身体成分的预后价值,但在非肌肉侵入性膀癌 (NMIBC) 中尚不清楚.
- 高风险的NMIBC患者接受了静脉注射Bacillus Calmette-Guérin (BCG) 治疗,并对身体成分指数进行了评估.
研究的目的:
- 评估身体质量指数 (BMI),骨肌肉指数 (SMI),psoas肌肉指数 (PMI) 和高危NMIBC患者的复发风险之间的关联.
- 探索身体成分在BCG治疗后预测疾病复发中的作用.
主要方法:
- 在诊断时使用计算机断层扫描 (CT) 评估身体组成.
- 萨科佩尼亚是使用性别特定的切断值来定义的.
- 使用Kaplan-Meier,Cox回归 (线性和spline术语) 和梯度增强机器 (GBM) 模型分析了无复发生存 (RFS).
主要成果:
- 包括118名患者 (平均年龄71岁);在32个月的随访期间,25.4%的患者出现了复发.
- 萨科佩尼亚患病率差异很大 (6-66%),定义之间的一致性很低.
- 在BMI,SMI,PMI和复发风险之间观察到非线性U形关联,低值和高值的风险增加.
结论:
- 身体组成表现出高风险NMIBC中复发的非线性关联.
- 低和过量的身体和肌肉质量都可能对疾病控制产生不利影响.
- 在NMIBC中需要标准化,多参数和非线性风险建模,用于 Sarcopenia.
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