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PBPK建模解决了口服吸收介导的药物相互作用

Xinyuan Zhang1, Grace Fraczkiewicz1, Viera Lukacova1

  • 1Simulations Plus, Inc., P.O. Box 12317, Research Triangle Park, NC, 27709, USA.

Drug metabolism and pharmacokinetics
|February 8, 2026
PubMed
概括

基于生理学的药理动力学 (PBPK) 建模有助于预测药物吸收如何受到相互作用的影响,例如胃pH或食物的变化. 这种方法有助于在开发过程中评估药物的安全性和有效性.

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