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Updated: Feb 10, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
08:34

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Published on: December 18, 2017

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免疫细胞表观遗传控制中的TET2:对炎症反应和与年龄相关的病理学的影响

Tomasz Obrebski1, Marta Maleszewska2, Stanislaw Dunin-Horkawicz3

  • 1Cellular Neurobiology Research Group, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Warsaw, Poland.

The Journal of biological chemistry
|February 8, 2026
PubMed
概括

十-十一转位2 (TET2) 酶修改DNA甲基化,影响基因表达和免疫细胞功能. TET2突变与白血病,衰老和炎症性疾病有关,强调了其治疗潜力.

关键词:
通过DNA甲基化.动脉样硬化 动脉样硬化克隆性血液形成 (clonal hematopoiesis) 是一种细胞形成的过程.细胞因子表达的表达方式缺血性中风 中风神经退行症的神经退行症

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