临床药剂师领导实施静脉至口服抗菌素切换协议:一个前性的准实验性研究
Fatma Gul Yumrucu1, Emre Kara1, Leyla Yumrukaya2
1Hacettepe University, Faculty of Pharmacy, Department of Clinical Pharmacy, Ankara, Türkiye.
临床药剂师干预在符合条件的患者中显著增加了静脉输入口服 (IVOS) 转换率,改善了抗菌药物降级和降低了成本,而不会影响患者的治疗结果.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 早期的静脉输入口服转换 (IVOS) 对于优化抗菌药物治疗,最大限度地减少并发症和改善药物经济结果至关重要.
- 临床药剂师的参与是提高IVOS率和促进抗菌药物管理的关键.
研究的目的:
- 评估临床药剂师领导的多模式干预对IVOS率的影响.
- 评估标准化IVOS协议和医生教育在促进及时缓解治疗升级方面的有效性.
主要方法:
- 进行了前后前性研究,比较了干预前后IV抗菌剂的使用情况.
- 一个专家小组确定了IVOS资格的纳入标准.
- 干预包括一个标准化的协议,医生教育和药剂师对IVOS的建议.
主要成果:
- 接受IVOS的合格患者比例在干预后从29.0%增加到54.0% (p<0.001).
- 药剂师的转换建议在59.6%的病例中被医生接受.
- 观察到抗微生物药物支出大幅降低成本,但对临床结果或患者安全没有不利影响.
结论:
- 临床药剂师主导的干预措施有效地增加了IVOS率,促进了适当的抗微生物降级.
- 这些举措优化了抗微生物药物利用,并支持了抗微生物药物管理计划.
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