毛囊淋巴瘤与标签环细胞形态:对31例病例的临床病理学分析
Xenia Parisi1, L Jeffrey Medeiros2
1Department of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA; Department of Pathology, Texas Children's Hospital, Austin, TX, USA.
Human pathology
|February 8, 2026
概括
这项研究详细介绍了31例带有密封环 (SR) 细胞的卵泡淋巴瘤 (FL),发现这些罕见的FL变体与经典FL相似. 基因分析揭示了FL中常见的突变,支持它们的分类.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 毛囊性淋巴瘤 (FL) 是一种常见的非霍奇金淋巴瘤.
- 标签环 (SR) 细胞在FL中很罕见,对其临床和生物特征的数据有限.
研究的目的:
- 为了描述毛囊淋巴瘤与密封环细胞 (FL-SR) 的最大病例系列.
- 描述FL-SR.的临床,形态,免疫类型和遗传特征.
- 为了将FL-SR与经典FL进行比较.
主要方法:
- 对31个FL-SR病例的回顾性分析.
- 对组织病理学的审查,包括形态学和分级.
- 免疫组织化学和流细胞测量用于免疫类型.
- 光在位杂交 (FISH) 用于IGH::BCL2.
- 针对基因突变的下一代测序 (NGS).
主要成果:
- 发现了31例FL-SR病例,占FL诊断的<0.05%.
- 平均年龄为65岁,74%的患者患有晚期疾病.
- FL-SR显示了典型的FL免疫类型 (泛B细胞+,CD10+,BCL2+,BCL6+).
- IGH::BCL2融合检测到所有测试的病例.
- 在FL中常见的KMT2D和TNFRSF14中,NGS发现了突变.
结论:
- FL-SR病例很少见,但与经典的FL具有共同的形态和免疫类型特征.
- 存在SR细胞并不会从根本上改变FL的生物学.
- 这项研究提供了最大的FL-SR和初始NGS数据系列,扩大了对这种变体的理解.
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