慢性鼻炎与鼻的临床缓解:来自意大利鼻炎网络 (RINET) 的德尔菲共识
Enrico Heffler1, Alberto Macchi2, Ernesto Pasquini3
1Department of Biomedical Sciences - Humanitas University - Pieve Emanuele (MI), Italy; Personalized Medicine, Asthma and Allergy unit - IRCCS Humanitas Research Hospital - Rozzano (MI), Italy.
The journal of allergy and clinical immunology. In practice
|February 8, 2026
概括
本研究使用标准化标准定义了使用鼻息肉 (CRSwNP) 的慢性鼻炎的临床缓解. 新的定义旨在改善临床实践中的治疗可比性和目标缓解.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 临床治疗学 临床治疗学
背景情况:
- 慢性鼻炎与鼻息肉 (CRSwNP) 的临床缓解在生物疗法中越来越重要.
- 目前的CRSwNP缓解定义不一致,阻碍了研究的可比性和临床应用.
- 需要标准化的标准来确定缓解作为治疗目标.
研究的目的:
- 建立一个多学科的,基于证据的定义,用于CRSwNP的临床缓解.
- 整合症状,内镜,治疗和缓解评估时间标准.
- 评估CRSwNP的复合缓解得分的专家共识.
主要方法:
- 一个三轮的德尔菲共识过程,涉及意大利鼻炎网络 (RINET) 的专家.
- 专家们以5点的利克特级别对陈述进行评分,以达到≥70%的共识或不同意见.
- 使用描述性统计数据来分析反应的趋同和稳定性.
主要成果:
- 在四个领域的缓解标准达成共识:时间 (≥12个月),没有全身皮质类固醇/手术,症状值 (SNOT-22 <20,VAS ≤3) 和内镜评分 (NPS/mLRS 0 完全,≤2 部分).
- 完全和部分缓解,持续缓解 (≥24个月) 和加权复合缓解得分得到一致同意.
- 该共识为CRSwNP的完全和部分缓解提供了明确的标准.
结论:
- 该研究提出了首个在CRSwNP中完全和部分临床缓解的操作性,多领域定义.
- 这些标准由多学科小组与患者的意见一起制定,为标准化评估提供了实际框架.
- 拟议的定义支持将缓解作为CRSwNP管理中的治疗目标.
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