24小时是足够的吗? 在新生儿胃分裂中,在腹壁关闭后评估预防性抗生素持续时间
Anna Zrinyi1, Anna Shawyer1, Richard Keijzer1
1Division of Pediatric Surgery, Department of Surgery, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Journal of pediatric surgery
|February 8, 2026
概括
在胃关闭24小时后停止服用预防性抗生素并没有增加感染风险. 这一发现支持目前针对无并发病例的指导方针,表明较短的抗生素疗程是安全有效的.
科学领域:
- 儿科手术 儿科手术
- 新生儿护理 新生儿护理
- 预防传染病 预防传染病
背景情况:
- 目前美国儿科外科协会 (APSA) 的指导方针建议在关闭后24小时停止预防性抗生素治疗,以隔离管理的胃患者.
- 支持这种有限的抗生素疗程推的证据很少.
- 这项研究基于关闭后的抗生素持续时间评估了感染率.
研究的目的:
- 为了确定在关闭后短时间 (≤24小时) 的预防性抗生素治疗是否与较长时间的治疗相比,在胃病患者中感染率更高.
- 提供支持或反驳当前APSA建议的证据.
主要方法:
- 在53名新生儿的回顾性评估中,用一个静止室管理的胃 (1991-2022年).
- 患者被分为短期 (≤24小时) 和长期 (>24小时) 抗生素组.
- 关闭后30天内感染是主要结果,使用后勤回归分析.
主要成果:
- 感染发生在短期治疗组的57% (16/28) 和长期治疗组的44% (11/25).
- 长期抗生素与短期抗生素感染的调整后几率比为0.82 (95% CI=0.25-2.65,p=0.74).
- 两组之间没有观察到感染率的统计学上显著差异.
结论:
- 在腹壁关闭后长达24小时的预防性抗生素的停用与无并发性胃瘤感染的风险增加无关.
- 这些发现支持目前的APSA建议,即在治疗结束后24小时内停止预防性抗生素.
- 这支持对抗生素在胃化治疗中的使用采取保守的方法.
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