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在患有口腔状细胞癌的患者中,辅助放射治疗的时间是否会影响存活率?
Aaron Hui1, Bita Fathipour2, Mohamed El-Rabbany3
1Resident, Department of Oral & Maxillofacial Surgery, University of Washington, Seattle, WA.
概括
在手术后6周内开始术后放射治疗 (PORT) 可以改善口腔状细胞癌 (OCSCC) 患者的整体存活率. 这一发现与当前治疗头癌的指导方针一致.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 头部和部手术 头部和部手术
背景情况:
- 此前的研究探讨了头部和部状细胞癌 (HNSCC) 的术后放射治疗 (PORT) 时间.
- 及时启动PORT对口腔状细胞癌 (OCSCC) 存活率的影响仍未得到研究.
研究的目的:
- 为了确定在6周内启动PORT与手术后6至12周之间是否会影响OCSCC患者的整体存活率 (OS).
- 为优化OCSCC治疗方案提供基于证据的建议.
主要方法:
- 使用国家癌症数据库 (NCDB) 从2004年至2019年进行的回顾性队列研究.
- 确定的OCSCC患者接受了治疗性手术和PORT治疗.
- 基于PORT启动时间 (在6周内与6-12周内) 分析的整体存活率 (OS),使用多变量考克斯回归.
主要成果:
- 总共有32,743名OCSCC患者被分析.
- 与6-12周相比,在6周内启动PORT与改善的OS有关 (HR1.08;P = .037).
- 放射治疗的持续时间没有显著影响OS (HR 1.00;P = .4).
结论:
- 在6周内开始PORT与OCSCC患者的更好的生存结果有关.
- 结果支持遵守NCCN关于及时启动PORT的指导方针.
- 优化PORT时间可能会提高OCSCC的治疗疗效.
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