在澳大利亚,法里西马布治疗未经治疗的神经血管AMD的12个月现实世界结果
Mark Gillies1, Yohei Hashimoto1, Rahman Nazari2,3
1Save Sight Institute, The Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Clinical & experimental ophthalmology
|February 8, 2026
概括
法里西马布在治疗新血管与年龄相关的黄斑变性 (nAMD) 中显示出安全性和有效性. 与aflibercept相比,这种新疗法对nAMD病变活性产生了更大的影响.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理疗法 药理疗法 药理疗法
背景情况:
- 神经血管与年龄相关的黄斑变性 (nAMD) 在视力丧失方面构成了重大挑战.
- 目前的治疗方法旨在控制疾病活动并保持视力敏.
- 评估像法里西马布这样的新型治疗药物对于推进nAMD管理至关重要.
研究的目的:
- 评估法里西马布在未经治疗的眼睛中与nAMD的有效性和安全性.
- 在现实世界中,将法里西马布的结果与阿弗利塞普特进行比较.
- 调查关键的疗效标志物,包括视力敏度和病变活性.
主要方法:
- 使用前性设计的注册表进行回顾性队列研究.
- 包括接受faricimab (2023年1月至2024年9月) 和aflibercept (2022年之前) 的未经治疗的nAMD眼睛.
- 使用重叠权重进行比较,分析视力敏度,病变活动,治疗间隔和12个月后访问频率.
主要成果:
- 法里西马布治疗导致视力敏度平均增加4个字母.
- 71%的病变在12个月内实现了不活动,平均不活化时间为10.3周.
- 与aflibercept相比,Faricimab显示出明显更高的无活化率,并且在≥12周的间隔内获得了更多的眼睛.
结论:
- 费里西马布是一种安全有效的治疗选择,用于未经治疗的nAMD.
- 与aflibercept相比,Faricimab在控制nAMD病变活动方面表现出更高的疗效.
- 这些发现支持法里西马布在管理nAMD中的作用,可能提供更好的结果.
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