识别风险喘表型:过敏和反复感染预测严重疾病
Emilie Johanning Bari1, Susanne Hansen1,2, Patrik Sandin3
1Respiratory Research Unit, Department of Respiratory Medicine and Infectious Diseases, Bispebjerg Hospital, Copenhagen, Denmark.
概括
过敏性喘与使用抗生素治疗的复发性呼吸道感染相结合,显著增加患严重喘的风险. 这些因素是独立的和附加的预测因素,强调了有针对性的预防策略的需要.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 喘的严重程度受到复杂的免疫学和环境因素的影响.
- 过敏性喘与增加对呼吸道感染的易感性有关.
- 过敏和抗生素治疗感染在严重喘进展中的联合作用需要评估.
研究的目的:
- 评估过敏性喘和需要抗生素的复发性呼吸道感染 (RRI) 之间的关联.
- 确定这些因素是否会增加患严重喘的风险.
主要方法:
- 使用瑞典国家数据 (2014-2019) 进行基于注册表的队列研究.
- 确定的轻度至中度喘患者 (2014年) 过敏性喘是由抗过敏药物处方定义的.
- 根据下呼吸道感染的≥2个抗生素处方定义的RRI (2015-2016).
- 评估了使用ERS/ATS标准的严重喘发展 (2017-2019).
主要成果:
- 在113,393名患者中,有21.8%患有过敏性喘;RRI在过敏性喘中更频繁 (7.5%对5.9%).
- 0.77%患有严重的喘;发生率在患有过敏喘和RRI (2.0%) 的患者中最高.
- 患有过敏性喘和RRI的患者患有严重喘的风险增加了3.47倍,在调整后一致.
结论:
- 过敏性喘和用抗生素治疗的呼吸道感染是严重喘的独立和附加预测因素.
- 这些发现确定了严重喘的临床可行的风险概况.
- 结果可能会为喘管理中的有针对性的预防策略提供信息.
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