白质微结构变化调解阿尔茨海默病多基因风险与临床无症状成年人认知表现之间的关联
Rui Zou1,2, Kaito Takabayashi1, Christina Andica1,2,3,4
1Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
概括
阿尔茨海默病多基因风险得分与无症状成年人的白质变化和认知差异有关. 这些白质变化部分解释了遗传风险和认知表现之间的联系.
科学领域:
- 神经成像是一种神经成像.
- 遗传学 遗传学 是一个
- 认知神经科学 认知神经科学
背景情况:
- 阿尔茨海默病 (AD) 是一种进展性神经退行性疾病,具有重要的遗传成分.
- 虽然阿波利波蛋白E ε4是已知的危险因素,但AD越来越多地被视为多基因.
- 多基因风险对白质 (WM) 微观结构和临床前阶段认知的影响尚不清楚.
研究的目的:
- 为了研究阿尔茨海默病多基因风险评分 (ADPRS) 和WM微观结构之间的关联.
- 为了检查ADPRS,WM微观结构和临床无症状成年人的认知表现之间的关系.
- 为了确定WM微观结构是否调解ADPRS和认知功能之间的联系.
主要方法:
- 分析了来自36400名 (45-83岁) 个体的英国生物库数据.
- 从48个WM片段中提取扩散张力成像和神经质定向分散和密度成像指标.
- 应用一般线性模型和调解分析来评估关联和调解效应.
主要成果:
- 较高的ADPRS与减少的分数异性质和WM区域的细胞内体积分数相关.
- 随着较高的ADPRS,观察到扩散度指标 (平均,轴向,辐射) 和同位体体积分数的增加.
- ADPRS与执行功能,情节性记忆和处理速度的表现较差有关,WM变化部分介导了这些效应.
结论:
- 阿尔茨海默病多基因风险评分与无症状个体的特定白质微观结构变化有关.
- 这些白质变化与微妙的认知差异有关.
- 白质微结构变化部分介导了多基因阿尔茨海默病风险和认知表现之间的关系.
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