在西班牙的儿科人口中接种COVID-19疫苗后的不良事件
M Ángeles Rivas Paterna1, Carla Pérez Ingidua2, Ana B Rivas Paterna3
1Unidad de Cuidados Intensivos Pediátricos y Unidad de Recuperación Postanestésica, Hospital Clínico San Carlos, Madrid, Spain.
Anales de pediatria
|February 8, 2026
概括
COVID-19 Comirnaty®疫苗对5至11岁的儿童是安全的,在西班牙的一项真实研究中显示,大多数是轻微的副作用. 大多数不良药物反应是注射部位疼痛,发烧和头痛,只有少数严重病例.
科学领域:
- 儿科疫苗学 儿科疫苗学
- 公共卫生 公共卫生
- 免疫学 免疫学 免疫学
背景情况:
- 西班牙于2021年12月开始为5至11岁儿童接种COVID-19疫苗.
- 有关mRNA疫苗技术和家长犹的担忧被注意到.
- 对于儿科COVID-19疫苗安全性的现实世界数据有限.
研究的目的:
- 评估儿童COVID-19疫苗接种后药物不良反应 (ADR) 的频率和特征.
- 提供现实世界的安全数据,以告知公共卫生政策.
主要方法:
- 在西班牙,对2126名5至11岁儿童进行了前性观察性研究.
- 通过采访,健康记录和登记册收集的数据.
- 副反应由专家委员会评估因果关系和严重程度.
主要成果:
- 35.6%的儿童经历了至少一个ADR,报告了1437次反应.
- 大多数副作用是轻微的 (99.5%),包括注射部位疼痛 (57.1%),发烧 (11.1%),和头痛 (5.7%).
- 第二剂后没有观察到反应性增加;只有一个严重的不良反应发生.
结论:
- 在现实条件下,Comirnaty®疫苗在儿童中显示出良好的安全性.
- 副作用主要是轻微的和自我限制的,需要最小的医疗干预.
- 这项研究支持COVID-19疫苗接种在这个儿科年龄组的安全性.
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