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Updated: Feb 10, 2026

Genome Editing in Mammalian Cell Lines using CRISPR-Cas
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Genome Editing in Mammalian Cell Lines using CRISPR-Cas

Published on: April 11, 2019

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使用Cas-CLOVER系统评估CHO细胞中的基因编辑

Tiffany McLamarrah1, Efecan Aral1, Michael Hoffman1

  • 1Mammalian Platform, Global CMC Development, Framingham, Massachusetts, USA.

Biotechnology progress
|February 8, 2026
PubMed
概括

使用Cas-CLOVER的基因编辑精确地准了中国仓鼠卵巢 (CHO) 细胞中的谷氨酸合成酶 (GS) 位点. 这导致单克隆抗体产生显著增强,显示标位增加了14.5倍.

关键词:
在CHO细胞中.卡斯·克洛弗 (Cas-CLOVER) 是一个名为卡斯·克洛弗的公司.生物制药生产生物制药生产基因编辑 基因编辑谷氨胺合成酶淘汰赛 (GSKO)

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