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相关概念视频

Plastic Deformations01:19

Plastic Deformations

472
Plastic deformation represents a fundamental concept in materials science, which explains the irreversible change in the shape of a material when it experiences stress beyond its elastic capability. This phenomenon is important in structural engineering, especially in designing and analyzing cantilever beams—structures that are securely fixed at one end and bear loads at the opposite end. When these beams are subjected to loads within their elastic range, they will return to their...
472
Plastic Deformations01:14

Plastic Deformations

473
It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
473
Subatomic Particles03:37

Subatomic Particles

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Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom.
113.6K
Interaction of EM Radiation with Matter: Spectroscopy01:12

Interaction of EM Radiation with Matter: Spectroscopy

3.3K
Electromagnetic (EM) radiation can be considered an oscillating electric and magnetic field propagating through a medium that can interact with matter in its path. The electric field in the radiation can interact with electrical charges in the atoms or molecules in the matter. On the other hand, the magnetic field can interact with the magnetic field in the atomic nucleus. The study of the interaction between electromagnetic radiation and matter is termed spectroscopy. Spectroscopy is the study...
3.3K
Temperature Dependent Deformation01:12

Temperature Dependent Deformation

412
In a nonhomogeneous rod made up of steel and brass, restrained at both ends and subjected to a temperature change, several steps are involved in calculating the stress and compressive load. Due to the problem's static indeterminacy, one end support is disconnected, allowing the rod to experience the temperature change freely. Next, an unknown force is applied at the free end, triggering deformations in the rod's steel and brass portions. These deformations are then calculated and added...
412
Deformations in a Symmetric Member in Bending01:18

Deformations in a Symmetric Member in Bending

525
When analyzing the deformation of a symmetric prismatic member subjected to bending by equal and opposite couples, it becomes clear that as the member bends, the originally straight lines on its wider faces curve into circular arcs, with a constant radius centered at a point known as Point C. This phenomenon helps to understand the stress and strain distribution within the member more clearly.
When the member is segmented into tiny cubic elements, it is observed that the primary stress...
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相关实验视频

Updated: Feb 10, 2026

A Robust Single-Particle Cryo-Electron Microscopy cryo-EM Processing Workflow with cryoSPARC, RELION, and Scipion
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A Robust Single-Particle Cryo-Electron Microscopy cryo-EM Processing Workflow with cryoSPARC, RELION, and Scipion

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在冷-EM 2D 分类后,用于粒子选择的点云变形建模.

Xuan Wang1, Zhengao Mo1, Fuwei Li2,3

  • 1School of Information and Intelligent Science, Donghua University, Shanghai, China.

BMC bioinformatics
|February 8, 2026
PubMed
概括
此摘要是机器生成的。

一个新的模型准确地测量了冷电子显微镜 (cryo-EM) 图像中的粒子变形. 这种方法可以过出错误分类的,变形的粒子,提高结构分析质量.

关键词:
数据过的数据过.变形的粒子变形的粒子单颗粒冷电磁器 (Cryo-EM) 是一种变量自动编码器变量自动编码器

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Single-Particle Cryo-EM Data Collection with Stage Tilt using Leginon

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科学领域:

  • 结构生物学 结构生物学
  • 生物物理学的生物物理.
  • 显微镜的使用方法

背景情况:

  • 低温电子显微镜 (cryo-EM) 对于高分辨率的宏分子结构确定至关重要.
  • 由于粒子变形,对单颗粒冷电磁图像进行分类是具有挑战性的.
  • 传统的二维分类方法错误地对变形颗粒进行分类,影响下游分析.

研究的目的:

  • 开发一种用于测量冷电磁图像中的粒子变形的新型模型.
  • 通过解决变形问题来提高粒子分类的准确性.
  • 为了提高冷EM结构分析的可靠性.

主要方法:

  • 开发了一个基于点云的变形测量模型.
  • 该模型集成了一个变量自编码器 (VAE) 与一个启发式点云匹配算法.
  • 变形值是为了识别和过粒子而计算的.

主要成果:

  • 该模型有效地识别和去除具有显著变形的粒子.
  • 对模拟和真实冷EM数据集 (TMV,MS2) 的实验证明了强大的分类 (F1:0.85-0.88).
  • 该方法保留了93% - 95%的结构细节,同时过了2D分类后的变形颗粒.

结论:

  • 该模型作为后处理步骤,以提高冷EM数据质量.
  • 通过去除变形或错误分类的粒子,可以提高分类的准确性.
  • 改进的粒子数据集导致了冷EM中更可靠的结构分析.