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Updated: Feb 10, 2026

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Methylated DNA Immunoprecipitation
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三甲基胺N-氧化物和相关代谢物可能调节DNA甲基化,并引发心血管疾病
Jiantao Ma1, Chao-Qiang Lai2, Xinmin S Li3
1Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Clinical epigenetics
|February 8, 2026
概括
三甲基胺N氧化物 (TMAO) 和相关代谢物与心血管疾病 (CVD) 有关. 这项研究发现了与这些代谢物相关的特定DNA甲基化位点,这表明表观遗传学在心血管疾病风险中的作用.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 代谢学 代谢学 代谢学
- 心血管疾病研究研究
背景情况:
- 三甲基胺N氧化物 (TMAO) 和相关代谢产物与心血管疾病 (CVD) 有关.
- 这些代谢物在DNA甲基化中的确切作用以及它们对心血管疾病发病的贡献在很大程度上仍未确定.
- 了解这些表观遗传联系可能会阐明疾病发展背后的新机制.
研究的目的:
- 调查TMAO和相关代谢物与DNA甲基化模式之间的关联.
- 为了确定由这些代谢产物表观遗传修饰的特定CpG位点.
- 在心血管疾病的背景下,探索这些代谢物-CpG关联的功能和临床相关性.
主要方法:
- 分析了心血管健康研究 (CHS) 和动脉样硬化多民族研究 (MESA) 中1356名成年人的数据.
- 使用液体染色学-并联质谱法 (LC-MS) 量化TMAO和五种相关代谢物.
- 使用Illumina BeadChip数组进行全基因组DNA甲基化分析,随后进行全表观基因组关联研究 (EWAS) 和在约430,000个CPG位点进行元分析.
- 通过基因组丰富分析和孟德尔随机化 (MR) 分析进行功能性探索.
主要成果:
- 在TMAO,贝他因,γ-布铁贝他因,卡尼丁,胆和克罗托诺贝他因中鉴定了143个显著的代谢物-CpG对 (FDR <0.05).
- 这些代谢物相关的CpG映射到108个基因,在CVD相关和免疫路径中显著丰富.
- 门德尔随机化确定了与冠状动脉疾病 (CAD) 相关的三种CpG,包括贝他因水平之间的新型反向关联,高甲基化在cg18705301 (NDUFAF1) 和降低CAD风险.
结论:
- 特定的DNA甲基化位点与TMAO和相关代谢物有显著的关联.
- 这些表观遗传修饰代表了肠道微生物群衍生代谢物与心血管疾病风险之间的潜在机械联系.
- 需要进一步的验证和临床研究来探索这些发现的治疗潜力.
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