血清pepsinogen水平的区域变化及其影响因素:一个多中心横截面研究
Huang Jiaojiao1, Yu Jiaying1, Tong Yuling2
1Department of General Practice/Health Management Center, School of Medicine, The Second Affiliated Hospital of Zhejiang University, Hangzhou, 310000, China.
Scientific reports
|February 8, 2026
概括
血清pepsinogen水平显示中国的区域差异,受H. pylori感染和饮食的影响,而不仅仅是胃病变. 这些发现可能会影响胃癌查策略.
科学领域:
- 胃肠病学和肝病学
- 生物标志物研究 生物标志物研究
- 流行病学 流行病学
背景情况:
- 血清pepsinogen (PG) 水平是胃健康的生物标志物.
- 以前的研究表明,生活方式和H. pylori影响PG水平.
- 独立于胃病变的PG水平的区域变化仍然不清楚.
研究的目的:
- 在中国各地调查基线血清PG水平的区域异质性.
- 为了确定影响血清PG水平的因素,独立于胃粘膜病变.
- 为了告知胃癌查协议的潜在调整.
主要方法:
- 一项涉及来自中国12个医疗中心的2902名个体的横截面研究.
- 测量血清pepsinogen I (PGI),pepsinogen II (PGII) 和PGI/II比率 (PGR) 的方法.
- 使用了胃镜,组织病理学,H. pylori测试 (组织学,血清学,呼吸测试) 和生活方式问卷.
主要成果:
- 在整个中国观察到基线血清PG水平的显著区域差异.
- H. pylori 感染 (目前或之前的根除),高盐摄入量和频繁的水果消费与血清PGR有关.
- 这些关联甚至在按H. pylori感染状况分层后仍然存在.
结论:
- 基线血清PG水平在中国表现出显著的区域差异,独立于胃粘膜病变.
- 杆菌感染和饮食因素 (盐,水果摄入) 是这些变化的关键影响因素.
- 区域特定和H. pylori分层的PG切线值可能是有效的胃癌查所必需的.
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