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Updated: Feb 10, 2026

Murine Colitis Modeling using Dextran Sulfate Sodium DSS
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium DSS

Published on: January 19, 2010

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通过STAT1-M1极化,NLRP12缺乏提高了DSS结肠炎中托法西替尼的有效性

Yun Yi1,2, Qiaofang Wei1,2, Siyu Chen1,2

  • 1Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.

Inflammation
|February 8, 2026
PubMed
概括

缺乏NLRP12会增强巨细胞炎症,增加对治疗性结肠炎的托法西替尼 (JAK抑制剂) 的敏感性. 这表明NLRP12和M1/M2巨细胞比率可能指导治疗.

关键词:
巨细胞是一个巨细胞.在NLRP12中使用NLRP12托法西提尼布 (tofacitinib) 是一种可怕的药物.性结肠炎是一种性结肠炎.

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