在美国成年人中,尿道金属暴露,全身炎症和晚期心血管--代谢综合征风险
Zhaoqi Yan1, Yifeng Xu1, Xiufan Du2
1Graduate School, China Academy of Chinese Medical Sciences, Beijing, China.
概括
高水平的和等尿金属与美国成年人心血管--代谢综合征 (CKM) 风险增加有关. 炎症生物标志物在这种关联中发挥着关键作用,突出了公共卫生问题.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 代谢综合征研究 代谢综合征研究
背景情况:
- 心血管--代谢综合征 (CKM) 构成了重大的公共卫生挑战.
- 尿道金属暴露是各种慢性疾病的潜在危险因素.
- 炎症生物标志物在金属暴露和CKM风险中介作用尚未完全理解.
研究的目的:
- 调查尿道金属暴露与美国成年人中晚期CKM风险之间的关联.
- 确定有助于CKM风险的特定金属.
- 检查炎症生物标志物在这种关系中的调解作用.
主要方法:
- 分析了来自国家健康和营养检查调查 (NHANES) 的6249名参与者.
- 利用受限制立方线 (RCS),多变量和分片逻辑回归,以及ROC曲线分析.
- 使用调解分析,通用加权量子总和 (gWQS) 回归和机器学习 (ML) 模型.
主要成果:
- 增加的多金属炎症指数 (MMII), (Cd) 和 (Co) 水平与增加的晚期CKM风险显著相关.
- 关联在更高的暴露水平上最明显,观察到线性剂量-反应关系.
- 炎症生物标志物 (WBC,NENO,SIRI,AISI,MHR,NHR) 调解了MMII/Cd/Co和高级CKM风险之间的联系.
结论:
- 在美国成年人中,尿液中较高的MMII,Cd和Co水平是晚期CKM的重要危险因素.
- 炎症生物标志物是从金属暴露到CKM风险的途径中的关键调解者.
- 这些发现强调了对金属暴露和炎症的监测对于预防CKM的重要性.
相关概念视频
01:38Inflammation
62.3K
Overview
62.3K
03:06Alkali Metals
24.9K
Group 1 elements are soft and shiny metallic solids. They are malleable, ductile, and good conductors of heat and electricity. The melting points of the alkali metals are unusually low for metals and decrease going down the group, while the density increases going down the group with the exception of potassium (Table 1).
Table 1: Properties of the alkali metals
Table 1: Properties of the alkali metals
24.9K
01:45Kidney Structure
75.5K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
75.5K
00:52What is Metabolism?
132.1K
Overview
132.1K
02:32Bonding in Metals
52.6K
Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”.
52.6K
02:37Metallic Solids
20.8K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.8K