使用超声波从含有乳液的酸和纤维素水凝中控制释放抗生素
Ziba Ghareh Nazi Fam1, Asia Winslow2, Mario L Fabiilli3
1Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Journal of biomedical materials research. Part A
|February 9, 2026
概括
这项研究引入了一种用于持续和超声波触发的万科米辛 (VAN) 释放的新型水凝,通过提供长时间的抗生素覆盖,改善脊髓融合手术后的感染预防.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 整形外科手术 整形外科手术
背景情况:
- 手术后感染是脊髓融合手术后的一个严重并发症,通常是由于抗生素耐药的细菌.
- 由于药物水平迅速下降,目前的短期抗生素预防和局部菌素 (VAN) 输送不足以预防晚发性感染.
研究的目的:
- 开发一种复合水凝系统,用于持续和超声波触发的万科米辛 (VAN) 释放.
- 评估开发的水凝对黄金葡萄球菌的药物释放动力学和抗菌疗效.
主要方法:
- 使用 perfluorohexane 制造水中的油中的水乳液,并将其嵌入酸盐或纤维素水凝中.
- 使用光谱光度和光标签量化VAN释放的量化.
- 对黄金葡萄球菌 (Staphylococcus aureus) 的抗菌活性的评估,有或没有超声波刺激.
主要成果:
- 与直接加载的水凝相比,乳液加载的水凝显著减少了VAN过早泄漏,在第一天显示>70%的保留率.
- 超声波的应用触发了显著的VAN释放,在7天后,阿尔金酸盐的药物输送增加了8.75倍,纤维素水凝的药物输送增加了27.5倍.
- 酸盐-乳液水凝显示出可测量的抗菌活性,通过超声波治疗显著增强 (p < 0.05).
结论:
- 开发的复合水凝平台可实现双模式VAN传输,提供持续的基线释放和按需的超声波触发强化.
- 该系统提供了对药物释放的空间和时间控制,有可能改善骨科手术中的感染预防策略.
- 基于酸盐的水凝显示出有效的VAN传递和抗菌作用的前景,将药物释放与长期覆盖的临床需求保持一致.
相关概念视频
01:28Load-frequency control
679
Load-frequency control (LFC) is vital for maintaining power system stability, ensuring that frequency and power flows remain within acceptable limits during load changes. Turbine-governor control eliminates rotor accelerations and decelerations following load changes. However, a steady-state frequency error persists when the change in the turbine-governor reference setting is zero. In an interconnected power system, each area agrees to export or import a scheduled amount of power through...
679
00:57Antibiotic Selection
60.1K
Overview
60.1K
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
711
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
711
01:30Development of Antibiotic Resistance
1.5K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.5K
01:28Energy-releasing Steps of Glycolysis
147.1K
Glycolysis is divided into two phases based on whether energy is utilized or released. While the first phase consumes ATP, the second phase produces energy in the form of ATP and NADH. The energy is released over a sequence of reactions that turns G3P into pyruvate. The energy-releasing phase—steps 6-10 of glycolysis—occurs twice, once for each of the two 3-carbon sugars produced during steps 1-5 of the first phase.
The first energy-releasing step—the 6th step of glycolysis...
The first energy-releasing step—the 6th step of glycolysis...
147.1K
01:19Impact Loading
713
Impact loading occurs when a moving object collides with a stationary structure, such as a rod with a uniform cross-sectional area fixed at one end. Under these conditions, the rod absorbs the kinetic energy from the striking object, leading to deformation and subsequent stress development. As the rod returns to its original position and reaches maximum stress, the absorbed energy, initially manifested as kinetic energy, transforms entirely into strain energy.
In cases of elastic deformation,...
In cases of elastic deformation,...
713