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Updated: Feb 10, 2026

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在患有大动脉d转移的儿童中,手术后的大脑氧气供应和神经发育

Anurudhya Karthikeyan^1,2, Rasheda Chowdhury^1,2, Ramy El-Jalbout^1,3

¹Centre de recherche Azrieli du CHU Sainte-Justine, Montreal, QC, Canada.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

|February 9, 2026

概括

在患有大动脉d转移 (TGA) 的婴儿中,术后大脑氧气输送与神经发育结果有关. 下脑血流和氧气输送可能预测TGA患者未来的发育风险.

科学领域:

儿童心脏病学儿童心脏病学
神经发育儿科神经发育儿科
生物医学工程生物医学工程

背景情况:

神经发育障碍在患有大动脉d转移 (TGA) 的儿童中很常见,但其原因尚未完全理解.
在TGA患者的术后结果需要进一步调查,特别是关于大脑发育.
大脑的氧气供应是大脑成熟和功能的一个关键因素.

研究的目的:

调查手术后大脑氧气供应与TGA新生儿神经发育结果之间的关联.
确定潜在的早期生物标志物来预测TGA儿童的神经发育风险.

主要方法:

床边光学神经监测用于评估TGA新生儿的脑血流指数 (CBF_i) 和脑氧输送指数 (CDO_2i) 和在手术/分娩后72小时内健康的对照.
在2岁时,使用贝利婴儿和幼儿发展量表来评估神经发育结果.
统计分析探讨了神经监测指数和神经发育得分之间的相关性,包括对心室隔膜缺陷的TGA (TGA-VSD) 和心室隔膜完整的TGA (TGA-IVS) 的子组分析.

主要成果:

与对照组相比,TGA新生儿的CDO_2i较低.
在整体TGA队列中,术后较低的CBF_i和CDO_2i与较差的运动复合,受体通信和总运动得分有关.
在TGA-IVS亚组中,对感受性沟通和运动尺度的关联较强,但在TGA-VSD亚组中不显著.

结论:

手术后大脑氧气可用性 (CBF_i和CDO_2i) 可能作为TGA儿童大脑成熟的早期生物标志物.
这些神经监测指数可以帮助识别具有未来神经发育挑战风险较高的婴儿.
需要对更大的队列进行进一步的研究来证实这些发现,特别是在子组分析中.

关键词:

在床边进行光学神经监测.大脑的血液流动.大脑血液动力学提供大脑氧气供应的大脑氧气供应大动脉的d-转移.扩散相关谱法 (DCS) 是一种扩散相关谱法.神经发育的结果.

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