三甲糖-葡萄糖指数与内血管治疗以及大缺血核心中风患者的结果
Shihai Yang1,2, Xiaolei Shi1, Chengsong Yue1
1Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
概括
甘油三糖 (TyG) 指数预测大缺血性中风患者的结果. 较高的TyG水平与更差的预后相关,特别是在接受内血管治疗 (EVT) 的人群中.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 大型缺血性核心中风带来了显著的死亡和发病风险.
- 甘油三糖 (TyG) 指数正在成为代谢功能障碍和心血管风险的标志物.
- 了解中风的预后因素,特别是与治疗有关的预后因素,对于患者管理至关重要.
研究的目的:
- 为了研究三甘-葡萄糖 (TyG) 指数与大缺血核心中风患者的预后之间的关联.
- 为了确定TyG指数的预后值是否在接受内血管治疗 (EVT) 和没有接受内血管治疗的患者之间有所不同.
主要方法:
- 一项多中心前性注册研究的亚分析,该研究涉及588名患有大缺血核心中风的患者.
- 甘油三糖指数 (TyG) 被计算和分析为连续变量,并分为四个四分位数.
- 评估的结果包括90天和90天死亡率的修改的兰金尺度 (mRS) 评分,并分析了TyG指数和治疗方式之间的相互作用.
主要成果:
- 较高的连续TyG指数与更糟糕的90天功能结局 (mRS) 和90天死亡率的增加显著相关.
- 当对TyG指数进行分类分析时,这种关联仍然很重要.
- 在TyG指数和治疗 (EVT与没有EVT) 之间观察到显著的相互作用,TyG更强烈地预测了EVT患者的预后. 当TyG指数超过9.18时,EVT的好处减少了.
结论:
- 甘油三糖 (TyG) 指数是患有大缺血核心中风的患者的有价值的预后标记.
- 在接受内血管治疗 (EVT) 的患者中,TyG指数的预后影响更为明显.
- 关于EVT的临床决策可能需要考虑TyG指数水平,因为其升高的值可以否定治疗效益.
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