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相关概念视频

Leaky Scanning02:28

Leaky Scanning

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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A scanning electron microscope (SEM) is used to study the surface features of a sample by using an electron beam that scans the sample surface in a two-dimensional manner. Typically, areas between ~1 centimeter to 5 micrometers in width can be imaged. SEM can be used to image bacteria, viruses, tissues as well as larger samples like insects. Conventional SEM gives a magnification ranging from 20X to 30,000X and spatial resolution of 50 to 100 nanometers.
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Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

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Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
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Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
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Polarography is a classical voltammetric technique used to analyze electrochemical reactions. This method applies a linear potential sweep to a dropping mercury electrode (DME), and the resulting current is measured. A dropping mercury electrode is commonly used as the working electrode in polarography. It consists of a capillary tube filled with mercury, where the tiny droplet forms at the tip. This droplet continuously drops from the capillary, creating a new electrode surface for each...
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相关实验视频

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Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation
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在单个扫描中自由运行的三维心脏细胞外体积映射,使用中部扫描对比注射.

Wonil Lee1,2, Paul Kyu Han1,2, Thibault Marin1,2,3

  • 1Yale Biomedical Imaging Institute, Yale University School of Medicine, New Haven, Connecticut, USA.

Magnetic resonance in medicine
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概括

这项研究引入了一种用于3D心脏细胞外体积 (ECV) 映射的新方法. 该技术可实现单扫描,自由运行成像与中部扫描对比注射,以改善心脏评估.

关键词:
心脏T1映射绘制地图心脏细胞外体积 (ECV) 映射电影影像成像技术 电影影像成像技术线性触点空间对齐 (LTSA) 是指线性触点空间对齐.

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科学领域:

  • 心血管成像 - 心血管成像
  • 磁共振成像 (MRI) 是一种磁共振成像技术.
  • 医学诊断 医学诊断 医学诊断

背景情况:

  • 准确的细胞外体积 (ECV) 地图绘制对于诊断和监测各种心脏疾病至关重要.
  • 传统的ECV测绘方法往往需要多次扫描或喘息,这限制了它们的临床适用性.
  • 开发一种单扫描,自由运行的3D ECV映射技术可以显著提高患者的舒适性和工作流程效率.

研究的目的:

  • 开发和验证一种新的自由运行,三维 (3D) 心脏磁共振成像 (MR) 方法用于细胞外体积 (ECV) 地图.
  • 为了在一个单一的,连续的扫描中实现ECV映射,在采集过程中施用对比剂.
  • 为了在一次成像会议中实现全面的3D心脏评估.

主要方法:

  • 使用单个,自由运行的3D心脏MRI扫描与反向恢复 (IR) 序列和破坏的梯度回声读数.
  • 使用对比剂进行中部扫描,并使用线性触点空间对齐 (LTSA) 模型重建动态图像.
  • 估计的前和后对比T1*值,合成的心脏影像图像,并使用测量血红素水平计算的3D心电图.

主要成果:

  • 在三名健康人群中使用3T核磁共振扫描仪证明了可行性.
  • 心电图显示与已建立的MOLLI方法有很好的一致性,心肌心电平均值为29.82%±2.45%.
  • 合成的电影图像准确地捕获了心脏运动,产生了63.3%±8%的射出分数,与文献值一致.

结论:

  • 成功开发了一种用于单个,自由运行扫描中的3D心脏ECV映射的新方法.
  • 该方法整合了对比注射中部扫描,允许高效和全面的心脏评估.
  • 这种技术为临床心血管成像和研究提供了有希望的进步.