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相关概念视频

Dynamic Equilibrium02:20

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A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
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Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
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All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
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Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
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Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
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器官在芯片上制造使用动态光罩

Terry Ching1,2,3,4, Shu-Yung Chang1,2, Takanobu Takenouchi1,5

  • 1Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, 487372, Singapore.

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概括
此摘要是机器生成的。

一个新的系统使用数字光图模式制造器官芯片 (OoC) 设备,加速创新. 这种方法允许复杂的设计和实时修改,加速OOC技术的研究采用.

关键词:
生物打印是一种生物打印技术.微流体学 在微流体学方面器官在芯片上的器官组织工程是组织工程.血管化的血管化.

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科学领域:

  • 生物医学工程 生物医学工程
  • 微流体学 微流体学
  • 组织工程是组织工程.

背景情况:

  • 器官在芯片 (OoC) 技术为生物医学研究提供了生理学上相关的微尺度模型.
  • 目前的制造方法,主要是软光刻,由于设计到原型的周期长,造成了瓶.
  • 加快OOC创新需要更灵活的制造流程.

研究的目的:

  • 开发一种多功能系统,以提高灵活性制造OOC设备.
  • 在OOC开发中克服传统软版画的局限性.
  • 为了实现OOC的快速原型和定制,以满足各种研究需求.

主要方法:

  • 这是一个新的系统,它结合了微室的 xurography 和微流体通道的数字光罩光图.
  • 对于OOC制造而言,使用直接光图的方法.
  • 数字光罩与微室系统的集成.

主要成果:

  • 实现了OOC制造中以前无法实现的特征,包括非网状的高度配置文件.
  • 启用了对通道设计的实时修改,用于诸如球形捕获等应用.
  • 展示了一个多功能系统,可以满足各种微环境设计要求.

结论:

  • 开发的系统通过直接的光图案,促进了OOC设备的快速制造.
  • 这种方法可以加速OOC设计的创新和科学界的采用.
  • 使用定制的OoC模型,有可能推进治疗查和疾病机制阐明.