病原体分布和抗菌素耐药性模式在儿童下呼吸道 菌 肺炎 肺炎
Boying Wu1, Zhe Zhang1, Chenbo Zhu1
1Department of Pediatrics, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, China.
由Mycoplasma pneumoniae引起的儿童下呼吸道感染通常涉及与表现出显著抗菌素耐药性的细菌共同感染. 长时间住院和先前使用抗生素是儿童多抗药性感染的关键危险因素.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 菌性肺炎肺炎 (MPP) 是儿童下呼吸道感染的常见原因.
- 了解共感染病原体的频谱及其抗菌素耐药性模式对于有效治疗至关重要.
研究的目的:
- 描述儿童MPP中呼吸道病原体的分布和抗菌素耐药性概况.
- 在这些患者中确定与多抗药性 (MDR) 感染相关的临床因素.
主要方法:
- 对125名儿科MPP患者的回顾性分析.
- 支气管支气管洗液分离物的微生物鉴定和抗菌敏感性测试.
- 多变量逻辑回归用于识别MDR感染的预测因素.
主要成果:
- 在同隔离的细菌病原体中观察到显著的抗微生物耐药性.
- 克莱布西拉肺炎菌,大肠杆菌和 Pseudomonas aeruginosa 对特定的抗生素有很高的耐药性.
- 黄金葡萄球菌和肺炎链球菌表现出显著的青素耐药性.
- 斯塔菲洛科克斯表皮球菌表现出对克林达米辛,勒沃弗洛克萨辛和青素的耐药性升高.
- 长时间住院 (≥14天),长时间使用抗生素 (≥7天) 和侵入性呼吸程序是MDR感染的独立风险因素 (p <0.05).
结论:
- 在儿科MPP中同隔离的细菌病原体有助于显著的抗菌素耐药性.
- 常规的病原体检测和敏感性分析对于指导向治疗至关重要.
- 这些措施对于打击儿科呼吸道感染中多药耐药性的上升至关重要.
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