空气中的颗粒物和大脑健康:PM2.5在血脑屏障功能障碍中的作用
Fátima Gimeno-Ferrer1, Lisa Teresa Porschen1,2,3, Frank Matthes1,2,3
1Division of Physiology & Vascular Biology, Faculty of Medicine, Institute of Theoretical Medicine, University of Augsburg, Augsburg, Germany.
概括
微细和超细颗粒物 (PM) 暴露会破坏血脑屏障 (BBB),导致神经炎症和神经系统疾病. 了解这些PM诱导的神经毒性机制是开发干预措施的关键.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 环境颗粒物 (PM),特别是细颗粒和超细颗粒,是与神经系统疾病相关的日益严重的环境问题.
- 血脑屏障 (BBB) 和神经血管单元是PM神经毒性作用的关键目标.
- 暴露于PM可以破坏BBB的完整性,导致神经炎症和功能障碍.
研究的目的:
- 审查目前关于PM如何影响BBB完整性和神经血管单元功能的证据.
- 阐明PM诱导的神经血管功能障碍中涉及的细胞特异反应.
- 为了确定潜在的细胞点治疗干预针对PM神经毒性.
主要方法:
- 本综述综合了有关PM对BBB的影响的现有研究.
- 它检查了内皮细胞,细胞周细胞,星球细胞和微质细胞在对PM暴露的反应中的作用.
- 讨论的机制包括氧化应激,炎症,紧密结节破坏和免疫细胞透.
主要成果:
- 暴露于PM会触发内皮细胞中的氧化应激和炎症,增加BBB的透性和粘附分子的表达.
- 细胞,星细胞和微质细胞在BBB破坏和神经炎症中发挥着动态作用.
- 粒子特性和宿主因素显著调节PM的神经毒性作用.
结论:
- 暴露于PM会引发一连串的BBB损伤和神经炎症,导致神经系统疾病.
- 在BBB和神经血管单元内的细胞点为干预提供了潜在的途径.
- 需要进一步的研究,以充分理解和减轻PM诱导的神经毒性.
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