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动态模拟辅助洞察到一个自组装的PD纳米酶的耳聋预防与内在准

Qin Huo¹, Guanrun Wang¹, Yanmei Mo¹

¹Department of Otolaryngology, Shenzhen Institute of Translational Medicine, Shenzhen Key Laboratory of Nanozymes and Translational Cancer Research, Medical Innovation Technology Transformation Center, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.

|February 9, 2026

概括

一种基于的新型纳米剂有效地穿越了血液迷宫屏障,以保护耳毛细胞免受损伤,为预防与年龄相关的听力损失提供了一个有希望的新策略.

科学领域:

生物材料科学生物材料科学
纳米医学是一种纳米医学.
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

与年龄相关的听力损失是一个日益增长的临床挑战.
由于血液迷宫屏障,目前的治疗方法难以到达耳毛细胞.
开发有效的治疗方法来预防聋至关重要.

研究的目的:

开发一种能够准耳毛细胞的新型纳米剂.
调查纳米剂对耳毒性的保护机制.
评估纳米剂在耳聋预防中的临床转化潜力.

主要方法:

一种聚甲酸协调抗氧化纳米剂 (Pd单原子纳米酶,Pd SAN) 的合成.
评估Pd SAN穿透血液迷宫屏障并保护毛发细胞的能力.
涉及铁灭抑制,氧化还原平衡和蛋白质结合模拟的机制研究.
在体内实验中评估听觉功能和耳结构.

主要成果:

Pd SAN表现出卓越的抗氧化能力和生物安全性.
Pd SAN有效地穿透了血液迷宫屏障,并保护了头发细胞免受Neomycin诱导的损伤.
通过维持细胞平衡,Pd SAN抑制了铁亡,并对关键毛细胞蛋白具有很高的结合亲和力.
在体内研究证实了Pd SAN在预防听觉值转移和耳损伤方面的有效性.

结论:

溶解体损伤,铁代谢失调和氧化应激是氨基糖化物中毒性的关键因素.
Pd SAN是一种精确结构的,尾向的抗氧化纳米材料,具有显著的临床转化潜力.
这项研究确立了预防聋症的新疗法策略.

关键词:

血液-迷宫屏障是血液-迷宫屏障.耳毛细胞是什么?耳聋的预防耳聋的预防 lysosomal 铁的稳态稳态.单原子纳米酶是一种单原子纳米酶.

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