[一个基于机器学习算法的多分子预测模型,用于状甲状腺癌中的淋巴结转移]
Zhijun Zhan1, Lu Chen2, Yan Sun2
1Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China. zhanzhijun@csu.edu.cn.
概括
这项研究确定了11个关键基因,用于预测乳头甲状腺癌 (PTC) 中的淋巴结转移 (LNM). 使用这些基因的机器学习模型在PTC患者的手术前LNM风险评估中显示出很高的准确性.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 准确的手术前淋巴结转移 (LNM) 状况评估在乳头甲状腺癌 (PTC) 对于个性化治疗至关重要,但目前的方法有局限性.
- 识别可靠的分子生物标志物可以显著提高PTC中的LNM预测准确性.
研究的目的:
- 在PTC中识别与LNM相关的关键分子生物标志物.
- 使用机器学习 (ML) 算法构建和验证LNM风险预测模型.
- 评估这些模型在PTC患者手术前决策中的临床实用性.
主要方法:
- 来自457名PTC患者 (TCGA) 的转录组数据使用DESeq2,edgeR,Limma和WGCNA进行了分析,以确定与LNM相关的基因.
- 拉索回归选择了11个核心特征基因,形成一个多变量逻辑回归模型 (模型2).
- 用ROC曲线,混矩阵,校准曲线,DCA和6个ML算法的交叉验证来评估模型性能.
主要成果:
- 11个标志性基因 (PI15,IL11,PLA2G5,LY6G6C,FAM178B,MUC21,FN1,PDZK1IP1,STAC2,TMPRSS4,WARS1P1) 被确定,在LNM患者中表达更高.
- 模型2显示出强大的预测性能,AUC为0.802 (训练) 和0.793 (验证),显示出跨性别稳定性.
- 该模型显示了预测和观察到的LNM概率之间的强烈一致,并显示了潜在的临床实用性,特别是在较低的风险值.
结论:
- 一个优化的11基因逻辑回归模型有效预测PTC患者的LNM风险.
- 该模型展示了强大的性能,跨性别稳定性和与各种ML算法的兼容性.
- 这种预测模型具有作为PTC中LNM评估和个性化治疗规划的术前决策支持工具的潜力.
更多相关视频
相关概念视频
Predicting Molecular Geometry
46.1K
VSEPR Theory for Determination of Electron Pair Geometries
46.1K
Detailed Structure and Function of Lymph Nodes
4.9K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
4.9K
Molecular Models
43.8K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.8K
Papillary Dermis
5.8K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.8K
Simplified Synchronous Machine Model
792
The Synchronous Machine Model is a fundamental tool in analyzing and ensuring the transient stability of power systems. This model simplifies the representation of a synchronous machine under balanced three-phase positive-sequence conditions, assuming constant excitation and ignoring losses and saturation. The model is pivotal for understanding the behavior of synchronous generators connected to a power grid, particularly during transient events.
In this model, each generator is connected to a...
In this model, each generator is connected to a...
792
Wind Turbine Machine Models
611
In the growing field of wind energy, incorporating wind turbine models into transient stability analysis is essential. Induction and synchronous machines are the primary models used, with induction machines being prevalent due to their simplicity and reliability.
Induction machines interact through the rotating magnetic field generated by the stator and the rotor. The key parameter is slip, which is the difference between synchronous speed and rotor speed relative to synchronous speed. Slip is...
Induction machines interact through the rotating magnetic field generated by the stator and the rotor. The key parameter is slip, which is the difference between synchronous speed and rotor speed relative to synchronous speed. Slip is...
611


