绝经的现代管理:我们正在衡量重要的事情吗?
Joscelyn Gan1, Michelle Steeper2, Tim Hillard3
1Melbourne Medical School, University of Melbourne, Melbourne, Australia.
BJOG : an international journal of obstetrics and gynaecology
|February 9, 2026
概括
绝经 (COMMA) 核心结果集 (COS) 的采用情况有所改善,但仍然有限. 虽然症状烦报告增加了,但像MHT这样的最前沿更年期治疗方法并没有完全根据所有COMMA COS结果进行评估.
科学领域:
- 生殖医学 生殖医学
- 临床试验方法论 临床试验方法论
- 患者报告的结果
背景情况:
- 更年期症状管理需要标准化的结果措施.
- 在更年期的核心成果 (COMMA) 倡议开发了核心成果集 (COS),以提高研究的一致性.
- 评估这些COS的采用对于推进更年期研究至关重要.
研究的目的:
- 评估COMMA COS在已发表的文献和临床试验注册表中的使用情况.
- 为了确定血管运动和泌尿生殖系统症状的前线治疗是否根据这些关键结果进行评估.
主要方法:
- 发表文献和国际临床试验注册表的方法审查.
- 对血管运动和泌尿生殖系统症状的随机对照试验 (RCT) 的分析.
- 通过审查历史和最近注册的试验,探索COS的采用,并根据COS评估治疗评估.
主要成果:
- 与COMMA COS的适度调整,显示出版后的增加.
- 在注册试验中,报告症状痛苦/烦的显著改善 (2%至62%).
- 对所有核心结局的前线治疗 (MHT,阴道雌激素) 的不完整评估,治疗满意度和失尿症 (9%) 的报道很低.
结论:
- 尽管有认可,但COMMA COS的全面采用是有限的.
- 在捕捉症状体验和影响方面观察到的改善.
- 呼吁优先考虑COMMA COS在更年期研究中的结果,以获得以患者为中心的证据.
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