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Updated: Feb 10, 2026

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鼻内人类NSC衍生的EVs疗法可以抑制炎症性微质转录组,NLRP3和cGAS-STING信号,在老年海马中

Leelavathi N Madhu1, Maheedhar Kodali1, Shama Rao1

  • 1Institute for Regenerative Medicine, Department of Cell Biology and Genetics, College Station, Texas A&M University Naresh Vashisht College of Medicine, College Station, Texas, USA.

Journal of extracellular vesicles
|February 9, 2026
PubMed
概括

来自神经干细胞 (hiPSC-NSC-EVs) 的鼻腔外细胞囊减少老年小鼠的神经炎症. 这种疗法通过调节微质通路来改善线粒体功能和认知表现.

关键词:
基因步行 (GeneWalk) 是一个很好的方法.大脑衰老 老龄化在海马体内,海马体炎症酶体 (inflammasomes) 是一种炎症酶体.干扰素-1的信号传输微质细胞中的微质细胞线粒体功能 线粒体功能通过基因激活蛋白激酶发出信号.神经炎症是一种神经炎症.在 scRNA-seqq 中.

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