复制证据表明精神分裂症患者全身衰老的速度加快
Ethan T Whitman1, Roberta Passiatore2,3, Annchen R Knodt1
1Department of Psychology and Neuroscience, https://ror.org/00py81415Duke University, Durham, NC, USA.
Psychological medicine
|February 9, 2026
概括
精神分裂症与加速衰老有关,正如一个新的神经成像生物标志物所表明的那样. 这一发现支持了在精神分裂症中快速衰老的假设,独立于遗传学或药物治疗.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症与慢性疾病的增加和寿命的缩短有关.
- 加速衰老是这种过度发病率和死亡率的假设贡献者.
- 由于测量精神分裂症衰老的局限性,测试这一假设一直是具有挑战性的.
研究的目的:
- 为了研究精神分裂症加速衰老的假设.
- 利用一种新的神经成像生物标志物来评估衰老的速度.
主要方法:
- 使用DunedinPoAm神经成像生物标志物来测量纵向衰老速度.
- 分析了四个神经成像数据集,共计2,096名参与者.
- 精神分裂症患者和对照组之间的老龄化速度比较.
主要成果:
- 精神分裂症始终与更快的衰老速度有关 (DunedinPoAm).
- 患精神病临床高风险的青少年和未受影响的兄弟姐妹没有表现出加速衰老.
- 精神分裂症的加快衰老并不能通过吸烟或使用抗精神病药物来解释.
结论:
- 这项研究提供了支持精神分裂症加速衰老的证据.
- 这些发现挑战了诸如家族风险,吸烟或药物效应等常见解释.
- 需要进一步的研究,以了解精神分裂症快速衰老的原因和潜在干预措施.
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