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Updated: Feb 10, 2026

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所有幸存者的神经认知结果:单一协议队列中的风险模式和个人资料
Barbara Johanne Thomas Nordhjem1, Liv Andrés-Jensen1, Kristian Mielke Christensen1
1Department of Pediatrics and Adolescent Medicine, Rigshospitalet, https://ror.org/035b05819University of Copenhagen, Copenhagen, Denmark.
Journal of the International Neuropsychological Society : JINS
|February 9, 2026
概括
急性淋巴细胞白血病 (ALL) 的长期幸存者面临着重大的神经认知挑战. 较年轻的诊断年龄和造血干细胞移植 (HSCT) 与较差的认知结果有关,突出显示需要有针对性的监测.
科学领域:
- 神经科学是一个神经科学.
- 儿科瘤学 儿科瘤学
- 临床心理学 临床心理学
背景情况:
- 急性淋巴细胞白血病 (ALL) 幸存者的生存率增加需要了解长期的神经认知后果.
- 越来越多的年轻人接受ALL治疗,因此需要对认知障碍进行评估.
研究的目的:
- 根据ALL2008协议治疗ALL的幸存者的认知功能.
- 确定认知表现和临床因素之间的关联,如诊断时的年龄,性别,治疗以来的时间,HSCT和神经毒性事件.
主要方法:
- 对83名ALL幸存者进行了神经认知测试,治疗后的中位数为7.24年.
- 使用年龄标准化的Z分数来评估表现,严重损伤定义为Z ≤ -2.0.
- 多重线性回归分析了认知结果和临床风险因素之间的关系.
主要成果:
- 虽然平均表现与标准相当,但38.6%的人至少在一个认知领域出现严重损伤,12%的人在两个或更多领域出现严重损伤.
- 诊断时年轻的年龄与较差的处理速度,执行功能和非语言推理相关.
- 造血干细胞移植 (HSCT) 与处理速度降低和非语言推理有关.
结论:
- 很大一部分ALL幸存者经历了严重的多领域认知障碍,尽管平均表现相似.
- 诊断时的年龄和HSCT是与认知缺陷相关的关键因素,这表明需要风险分层监测.
- 这些发现支持针对所有高风险的幸存者开发有针对性的认知干预措施.
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