通过线粒体激活通过Mito-activator复合体增强头发的生长
In Gi Lee1, Hyo Jeong Lim1, Eun Ji Kwon1
1Innogene Co. Ltd, Seoul, Korea.
International journal of cosmetic science
|February 9, 2026
概括
一种新的线粒激活器复合物 (MiAc) 通过刺激线粒体活动来促进头发生长. 临床试验表明,MiAc显著增加了头发密度和生长,没有副作用,为脱发提供了有希望的治疗方法.
科学领域:
- 细胞生物学 细胞生物学
- 皮肤病学 皮肤病学
- 线粒体生物学 线粒体生物学
背景情况:
- 脱发会影响生活质量,目前的治疗有副作用.
- 线粒体功能障碍与各种细胞过程有关,可能包括毛囊活动.
研究的目的:
- 研究一种新的线粒体激活器复合体 (MiAc) 的潜力,以刺激线粒体活动并促进头发生长.
- 评估MiAc在人类脱发治疗中的有效性和安全性.
主要方法:
- 使用人类皮肤乳头细胞 (hDPC) 和纤维细胞 (hDF) 的体外研究评估了线粒体活性 (ATP,内容测试).
- 使用AMPK抑制剂 (dorsomorphin) 探索线粒体活动在头发生长中的作用.
- 六个月的临床试验评估了MiAc配方对成人头发数量,密度和皮肤安全性的评估.
主要成果:
- 在实验室中,MiAc治疗增加了ATP水平,线粒体含量和头发生长因子的表达.
- MiAc抵消了dorsomorphin诱导的抑制,证实了线粒体活动与头发生长之间的联系.
- 临床试验表明,在24周内,头发密度和生长显著改善,没有报告的不良影响.
结论:
- 通过MiAc激活线粒体是促进头发生长的可行策略.
- 在人类的脱发治疗中,MiAc显示出显著的疗效和安全性.
- 这项研究确定了MiAc作为安卓发症和其他形式的脱发的有希望的治疗候选者.
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