立方体减记:全面审查和开发一个临床算法,以实现最佳的患者管理
Tiziano Lupi1, Fabio Esposito2, Alessia Romagnoli3
1Hospital Pharmacy, Local Health Unit Lanciano Vasto Chieti, Chieti, Italy.
对于预期寿命有限或多种并发性疾病的患者,可以安全地处方他类药物. 这一策略可以改善生活质量,没有严重的不良事件,支持共享决策.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 药理学 药理学是指药理学的学科.
背景情况:
- 类他类药物是通过降低LDL胆固醇来预防动脉样硬化心血管疾病的主要药物.
- 在预期寿命有限或多病症患者中,他类药物的益处可能会被增加的风险所抵消.
研究的目的:
- 系统地评估对他类药物停止处方的证据.
- 开发一种临床算法,以适当地停止使用他类药物.
主要方法:
- 在PubMed中进行了系统的文献搜索,使用"他类药物"和"处方药"或"处方药".
- 符合条件的研究根据设计,人口,结果和医疗保健专业人员的参与进行了分析.
主要成果:
- 56项研究符合纳入标准,包括真实研究,评论和随机对照试验 (RCT).
- 41%的研究报告说,他类药物不再处方带来了积极的结果,没有严重的不良事件,生活质量得到改善.
- 多学科团队参与了43%的抑郁症治疗干预.
结论:
- 静止剂降低处方对于某些患者来说是一种安全有效的策略,特别是那些预期寿命有限或并发症患者.
- 个性化,共享决策和多学科合作对于有效的抑郁症治疗至关重要.
- 需要进一步进行高质量的研究,特别是RCT,以完善临床指南.
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