尿中的咖啡因与咖啡因代谢物和湿性过活膀之间的关系:从NHANES 2009-2014数据进行的横截面研究
Junjie Ji1,2, Gongyue Liu1,2, Guoqing Chen1,2
1Department of Urology, School of Rehabilitation of Capital Medical University, China Rehabilitation Research Center, Beijing, China.
Neurourology and urodynamics
|February 9, 2026
概括
尿中的咖啡因及其代谢物与过度活性膀 (OAB) 的风险较低有关,这表明咖啡因代谢的改变可能会影响OAB的患病率. 这项研究分析了NHANES数据,以探索这种关系.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 代谢学 代谢学 代谢学
- 公共卫生 公共卫生
背景情况:
- 尿路咖啡因代谢物和湿性过活性膀 (OAB) 之间的关联尚不清楚.
- 调查这种关系对于理解潮湿OAB的潜在病因因素至关重要.
研究的目的:
- 检查尿咖啡因及其代谢物与美国人口中湿OAB患病率之间的关联.
- 探索咖啡因代谢途径在湿OAB风险中的作用.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2009-2014) 的横截面分析.
- 包括3395名参与者,他们有湿OAB,尿咖啡因/代谢物和共变体的数据.
- 应用加权单变量,多变量逻辑回归和受限立方线分析.
主要成果:
- 咖啡因摄入本身与湿OAB没有显著的关联.
- 增加的尿咖啡因,1,7-二甲基酸,1,3,7-三甲基酸,帕拉克桑丁和神胺水平显示出与湿OAB风险有显著的线性负相关性.
- 亚组和敏感性分析证实了这些发现的稳定性和意义.
结论:
- 总体咖啡因摄入量和湿OAB之间没有发现直接联系.
- 特定咖啡因代谢物的尿液水平与湿OAB相反相关,这表明咖啡因代谢途径的作用.
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