在早期NSCLC治疗中与Nivolumab结合的立体性废除性放射疗法的病理反应:一项2期研究
Gustavo Schvartsman1, Yasmin M Amirato2, Frederico Monfardini1
1Hospital Israelita Albert Einstein, São Paulo, Brazil.
JTO clinical and research reports
|February 9, 2026
概括
新辅助药尼沃卢马布与立体性废除性放射治疗 (SABR) 结合使用,在早期非小细胞肺癌 (NSCLC) 患者中显示出高的病理完整反应 (pCR) 率,这些患者有资格接受手术. 这种组合疗法需要进一步研究更广泛的NSCLC治疗应用.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 免疫治疗是一种免疫疗法.
背景情况:
- 立体除性放射治疗 (SABR) 是早期NSCLC不适合手术的标准,但复发率仍然很高.
- 将SABR与PD-1抑制剂结合起来是有希望的,但其对瘤微环境和病理反应的影响尚不清楚.
研究的目的:
- 评估新辅助药尼沃卢马布加SABR在可手术的早期NSCLC中的疗效和安全性.
- 为了确定这种综合新辅助治疗后的病理完整响应 (pCR) 率.
主要方法:
- 第二阶段,对25名NSCLC患者进行单臂研究 (≤4厘米,节点阴性).
- 三剂尼沃卢马布 (360 mg q21d) 与SABR同时服用,然后在辐射后10周进行手术.
- 主要终点:pCR率;次要终点:MPR,安全性,存活率,生物标志物分析.
主要成果:
- 观察到高的pCR率为79.2% (19/24名患者).
- 主要病理反应 (MPR) 在83.3%的患者中被观察到.
- 12个月无事件和整体存活率为84%,没有发生与治疗相关的死亡.
结论:
- 新辅助药尼沃卢马布和SABR在第一阶段NSCLC中实现了高PCR率.
- 对医学上不可操作的NSCLC需要进一步的研究,并探索在特定情况下省略手术.
相关概念视频
Piaget's Stage 2 of Cognitive Development
958
The preoperational stage, the second of Jean Piaget's four stages of cognitive development, spans approximately ages 2 to 7 and is characterized by the emergence of symbolic thinking. During this stage, children use language, images, and symbols to represent objects and concepts, enabling them to engage in imaginative and pretend play. This symbolic thinking supports children's ability to perform make-believe actions, such as imagining a broom as a horse or their hand as a phone, blending...
958
Phase Diagrams
50.4K
A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. These diagrams indicate the physical states that exist under specific conditions of pressure and temperature and also provide the pressure dependence of the phase-transition temperatures (melting points, sublimation points, boiling points). Regions or areas labeled solid, liquid, and gas represent single phases, while lines or curves represent...
50.4K
Phase Transitions
23.3K
Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
23.3K
Phase Transitions: Sublimation and Deposition
20.3K
Some solids can transition directly into the gaseous state, bypassing the liquid state, via a process known as sublimation. At room temperature and standard pressure, a piece of dry ice (solid CO2) sublimes, appearing to gradually disappear without ever forming any liquid. Snow and ice sublimate at temperatures below the melting point of water, a slow process that may be accelerated by winds and the reduced atmospheric pressures at high altitudes. When solid iodine is warmed, the solid sublimes...
20.3K
Stages of Infection
65.4K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
65.4K
Inductance: Single-Phase And Three-Phase Line
638
Understanding the inductance of transmission lines is crucial for efficient design and operation in electrical power systems. This discussion delves into the inductance characteristics of single-phase two-wire and three-phase three-wire transmission lines with equal phase spacing.
Single-Phase Two-Wire Line:
A single-phase line consists of two solid cylindrical conductors, denoted as x and y. Each conductor carries phasor currents ix and iy, respectively. Given that the sum of these currents is...
Single-Phase Two-Wire Line:
A single-phase line consists of two solid cylindrical conductors, denoted as x and y. Each conductor carries phasor currents ix and iy, respectively. Given that the sum of these currents is...
638


