胰岛素样生长因子1受体表达用于预测PD-1 / PD-L1抑制剂响应在下甲状腺状细胞癌
Wen-Jing Li1, Xiao-Lin Xu1, Li-Cheng Xu2
1Department of Otorhinolaryngology, Head and Neck Surgery The First Affiliated Hospital of Harbin Medical University Harbin China.
World journal of otorhinolaryngology - head and neck surgery
|February 9, 2026
概括
胰岛素样生长因子1受体 (IGF-1R) 表达预测了下甲状腺状细胞癌 (HPSCC) 的治疗反应. 用PD-1/PD-L1抑制剂向IGF-1R可能会改善结果,特别是在p16+ HPSCC中.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 胰岛素样生长因子1受体 (IGF-1R) 在癌症的发展和免疫调节中起作用.
- 在下支状状细胞癌 (HPSCC) 中IGF-1R的预后和预测意义仍然不清楚.
- 了解IGF-1R在HPSCC瘤免疫力中的作用对于开发向疗法至关重要.
研究的目的:
- 调查IGF-1R表达在HPSCC中的预后价值.
- 探索IGF-1R,p16状态和HPSCC中的瘤透免疫细胞之间的关联.
- 评估IGF-1R作为HPSCC免疫治疗反应的预测生物标志物的潜力.
主要方法:
- 使用TCGA HNSCC数据集分析IGF-1R,p16和瘤透免疫细胞之间的相关性.
- 免疫组织化学 (IHC) 和多重免疫组织化学 (mIHC) 用于评估IGF-1R,编程死亡配体 (PD-L1) 和p16+/p16-HPSCC标本中的免疫细胞密度.
- 该研究包括来自HPSCC患者的114个手术样本 (51 p16+,63 p16-).
主要成果:
- 在侵袭前线的瘤细胞和免疫细胞中观察到IGF-1R和PD-L1表达.
- 较高的IGF-1R和PD-L1表达,以及增加的CD68+和CD163+细胞密度,在p16-HPSCC中发现,与p16+HPSCC相比.
- 在p16+HPSCC中观察到PD-L1表达,CD68+巨细胞密度和IGF-1R表达之间的正相关性;在p16+HPSCC中,IGF-1R/PD-L1的联合表达更高.
结论:
- 与p16状态相比,IGF-1R表达可能是HPSCC中PD-1/PD-L1抑制剂反应的优越预测因素.
- 结合治疗包括IGF-1R抑制剂和PD-1/PD-L1阻断,对于p16+HPSCC患者来说是一个有前途的治疗策略.
- 需要进一步的研究来验证这些发现,并优化HPSCC的治疗策略.
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