人类口腔病毒1病毒病相关的儿科败血症与三相性尿路:一个病例报告
Shuwen Zhong1, Wenjie Shan1, Long Xiang2
1International Medical Department, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Translational pediatrics
|February 9, 2026
概括
人类口腔病毒1 (HBoV1) 作为唯一的病原体,可以引起儿科败血症. 这种病例显示出独特的三相性尿路,突出显示了HBoV1的系统性影响和先进诊断的需要.
科学领域:
- 儿童传染病 儿童传染病
- 病毒学 病毒学
- 关键护理医学 关键护理医学
背景情况:
- 人类口腔病毒1 (HBoV1) 是一个常见的儿科呼吸道病毒.
- 它作为严重全身疾病的唯一原因及其对泌尿系统的影响尚未完全理解.
研究的目的:
- 报告第一个由HBoV1病毒病引起的儿科败血症病例.
- 为了描述这位患者的新型三相性尿路.
主要方法:
- 一个4岁女孩患有败血症的病例报告.
- 血液元基因组下一代测序 (mNGS) 用于病原体识别.
- 泌尿道超声波和空虚后残留体积 (PVR) 的评估.
主要成果:
- 高负荷 HBoV1 病毒病症被确定为培养负性败血症中唯一的病原体.
- 患者表现出三相性尿路:无菌性皮尤里亚,败血症期间的正常成像,以及延迟的皮叶切除/增加的PVR.
- 尿路异常在2.5个月内消失.
结论:
- HBoV1可能是导致儿科败血症的唯一病原体.
- 尿路的发现表明一种由炎症介导的病变发生.
- 先进的诊断和纵向监测对于识别病毒性败血症和管理潜在的器官功能障碍至关重要.
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