患有高血压和阻塞性睡眠呼吸暂停综合征的患者中反应性高血压指数和内皮功能障碍标志物之间的相关性:一个横截面研究
Chaoping Yu1,2, Yue Liu1, Fengcheng Xu1,2
1Department of Cardiology, The Third Affiliated Hospital of Chengdu Medical College, Chengdu Pidu District People's Hospital, Chengdu, China.
Frontiers in cardiovascular medicine
|February 9, 2026
概括
这项研究发现,反应性高血压指数 (RHI) 可以预测高血压和阻塞性睡眠呼吸暂停低血压综合征 (OSAHS) 患者的血管内皮损伤. 在这种高风险人群中,RHI是评估内皮功能障碍的有价值指标.
科学领域:
- 心血管医学 心血管医学
- 睡眠医学 睡眠医学
- 血管生物学 血管生物学
背景情况:
- 内皮功能障碍是心血管疾病的一个关键因素.
- 高血压和阻塞性睡眠呼吸暂停低血压综合征 (OSAHS) 是常见的并发症,会加剧内皮功能障碍.
- 需要临床工具来分层内皮功能障碍严重程度在患有同时存在高血压和OSAHS的患者.
研究的目的:
- 调查联合高血压和OSAHS对血管内皮功能的影响.
- 探索反应性高血压指数 (RHI) 在评估本患者组内皮功能障碍中的有用性.
主要方法:
- 连续招募35-60岁的高血压患者,患有OSAHS.
- 测量呼吸暂停-呼吸暂停指数 (AHI),RHI和内皮损伤标志物 (VWF,VEGF,EMPs).
- 对AHI,RHI,高血压严重程度和内皮细胞标志物之间的相关性分析.
主要成果:
- 在AHI和RHI之间发现了显著的反相关性 (r = -0.58,P < 0.001).
- RHI显示了与VWF (r = -0.62,P < 0.001),VEGF (r = -0.63,P < 0.001) 和EMPs (r = -0.67,P < 0.001) 的显著反向关联.
- 增加的AHI,VWF,VEGF和EMP与减少的RHI有关,表明内皮功能障碍恶化.
结论:
- 反应性高血压指数 (RHI) 是评估高血压和OSAHS患者血管内皮功能的一个有价值的指标.
- 在这个高风险人群中,RHI可以预测血管内皮损伤的程度.
- 常规测量RHI可能有助于分层疾病负担和指导干预策略.
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