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Updated: Feb 10, 2026

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在预测新生儿败血症和死亡率中的血清介质蛋白18和22的评估:一个病例对照研究
Heba A Ahmed1, Amany Abbass1, Elsayed Abdelkreem2,3
1Department of Clinical and Chemical Pathology, Faculty of Medicine, Sohag University, Egypt.
Clinical medicine insights. Pediatrics
|February 9, 2026
概括
介质素-18 (IL-18) 和介质素-22 (IL-22) 显示出作为生物标志物的高潜力,用于新生儿败血症 (NS) 的早期诊断和预测死亡率. 在患有NS的新生儿中,这些炎症性细胞因子的水平升高与死亡风险增加密切相关.
科学领域:
- 新生儿免疫学 新生儿免疫学
- 发现生物标志物的发现.
- 临床诊断 临床诊断 临床诊断
背景情况:
- 新生儿败血症 (NS) 是婴儿死亡的主要原因,早期诊断仍然是一个重大的临床挑战.
- 炎症性细胞因子,包括IL-18和IL-22,涉及到对NS的免疫反应,可以作为早期诊断指标.
- 之前的研究表明NS患者的IL-18和IL-22水平升高,与死亡率相关.
研究的目的:
- 评估血清IL-18和IL-22水平的诊断准确性,以预测新生儿败血症.
- 评估IL-18和IL-22在预测被诊断为败血症的新生儿死亡率方面的实用性.
主要方法:
- 一项病例控制研究,涉及55名培养阳性败血症新生儿和34名健康对照.
- 使用酶相关免疫吸收试验 (ELISA) 量化了IL-18和IL-22的血清水平.
- 采用接收器操作特征 (ROC) 曲线分析来确定NS和死亡率的诊断性能.
主要成果:
- 与健康对照组相比,患有NS的新生儿的IL-18和IL-22中位数显著高于健康对照组 (P < .001两者).
- 在败血症新生儿中,与幸存者相比,非幸存者呈现出明显升高的IL-18和IL-22水平 (P < .001).
- ROC分析证实了IL-18和IL-22在预测NS (AUC 0.990和0.998) 和死亡率 (AUC 0.942和0.994) 中的优异诊断性能.
结论:
- 血清IL-18和IL-22显示出作为新生儿败血症早期检测的可靠生物标志物的巨大潜力.
- 这些细胞因子也是患有败血症的新生儿死亡率的有价值预测因素.
- 进一步的研究可以探索将IL-18和IL-22集成到临床实践中,以改善新生儿败血症管理.
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