无花果叶的生物活性和安全性:温度优化和FTIR认证
Ekarat Vasupen1, Kanokkarn Rabpairee2, Watcharaporn Toommuangpak2
1Faculty of Agricultural Innovation and Technology Rajamangala University of Technology Nakhon Ratchasima Thailand.
Food science & nutrition
|February 9, 2026
概括
富含抗氧化剂的无花果叶提取物在60°C干燥时表现出最佳的生物活性. 这些功能性食品成分对正常细胞是安全的,对癌细胞具有选择性毒性,表明抗癌潜力.
科学领域:
- 农业科学 农业科学
- 食品科学 食品科学 食品科学
- 生物化学 生化学
背景情况:
- 无花果 (Ficus carica L.) 叶子是一种未充分利用的农业副产品,具有作为功能性食品成分的潜力.
- 消费者对功能性食品的兴趣正在增加,这凸显了探索新来源的必要性.
研究的目的:
- 调查干燥温度对四种无花果叶品种水提取物的生物活性和安全性的影响.
- 评估无花果叶提取物作为功能性食品成分的潜力,并探索它们的选择性抗癌特性.
主要方法:
- 四种无花果叶品种 (BTM,黑紫,朗格德奥特,苏丹) 在50°C至80°C的温度下干燥.
- 分析了水提取物中总含量 (TPC),总黄含量 (TFC) 和抗氧化活性 (DPPH,ABTS,FRAP).
- 福利埃变换红外 (FTIR) 光谱与主要成分分析 (PCA) 用于品种歧视. 使用对Caco-2,HepG2和THLE-2细胞的MTT测定来评估安全性.
主要成果:
- 所有品种的最佳生物活性干燥温度为60°C (p < 0.05).
- 朗格德奥特品种显示出优越的生物活性 (TPC = 53.8 mg GAE/g,DPPH IC50 = 0.96 mg/mL).
- 较高的温度 (70°C-80°C) 降低了生物活性,而FTIR-PCA实现了96.8%的品种区分精度. 提取物显示出出色的安全性 (IC50 = 7-15.3 mg/mL) 和对HepG2癌细胞的选择性细胞毒性 (2.18倍选择性).
结论:
- 无花果叶提取物具有显著的生物活性和出色的安全性,验证了它们作为功能性食品成分的使用.
- 60°C的最佳干燥温度保持了生物活性,FTIR-PCA对质量控制是有效的.
- 无花果叶提取物对癌细胞具有选择性毒性,因此需要进一步研究其抗癌机制.
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