长期印度视神经炎研究 (狮子研究):在印度人口的视神经炎的临床,成像特征和视觉行为超过二十年
Selvakumar Ambika1, Santhakumar Durgapriyadarshini1, Shikha Talwar Bassi1
1Department of Neuro Ophthalmology, Sankara Nethralaya, Chennai, Tamil Nadu, India.
Frontiers in ophthalmology
|February 9, 2026
概括
这项研究分析了印度20多年的视神经炎 (ON),发现异形ON和NMOSD-ON比MS-ON更常见. 视觉结果与其他亚洲研究相似,呈现时有显著的视觉盘胀.
科学领域:
- 眼科医生 眼科 眼科
- 神经眼科神经眼科
- 神经学 神经学
背景情况:
- 视神经炎 (ON) 是一种影响视神经的炎症状况,在不同的人群中患病率和临床过程各不相同.
- 了解印度人口中的特定疾病特征对于准确的诊断和管理至关重要.
研究的目的:
- 在20年的时间里,调查视神经炎的印度患者的人口结构,临床特征和治疗反应.
- 将结果与国际研究进行比较,例如光神经炎治疗试验 (ONTT).
主要方法:
- 从1997年到2017年,对314名视神经炎 (ON) 患者的医疗记录进行了回顾性审查.
- 对临床资料,神经成像和治疗后视觉结果的分析.
- 对NMO抗体 (NMO Ab) 和MOG抗体 (MOG Ab) 的检测.
主要成果:
- 该研究包括314名患者的406只眼睛;女性 (60%) 和单边参与 (70%) 是常见的. 平均年龄为36.28岁.
- 在呈现时,50%的患者存在光盘. 治疗后视力明显改善 (日志MAR 0.34).
- 在26.75%的患者中观察到复发. 异形性ON (88.8%) 和NMOSD-ON (19个阳性NMO Ab) 比MS-ON (5.8%) 更为普遍.
结论:
- 印度视神经炎队列表现出独特的特征,包括较高的视盘胀率和与MS-ON相比,异形ON和NMOSD-ON的更大流行率.
- 这个群体的视觉结果与其他亚洲研究相似,但与ONTT不同,突出区域差异.
- 建议进行进一步的前性研究,以阐明自然疾病过程,神经学关联和最佳治疗策略.
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