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维生素D缺乏和怀孕结果:基于LC-MS/MS的评估在中国西南地区
Mao Zheng1, Yali Wang1, Ning Zou1
1Department of Clinical Laboratory, Deyang People's Hospital, Deyang, China.
维生素D缺乏症在中国德阳的孕妇中很常见,尤其是在怀孕早期. 维生素D3补充剂比D2更有效.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 维生素D不足是一个重要的全球健康问题.
- 中国的孕妇特别容易受到维生素D缺乏的影响.
- 在使用精确的LC-MS/MS方法的情况下,中国西南部维生素D状况的数据有限.
研究的目的:
- 为了调查在中国德阳的孕妇中维生素D缺乏的患病率和危险因素.
- 探索维生素D缺乏和怀孕结果之间的联系.
- 为了比较维生素D2和维生素D3补充剂的疗效.
主要方法:
- 这是一项对2742例怀孕的回顾性队列研究.
- 使用LC-MS/MS测量了血清25(OH) D2和25(OH) D3水平.
- 后勤回归分析确定了风险因素和与结果的关联.
- 评估了维生素D补充剂的疗效.
主要成果:
- 62.5%的参与者有维生素D缺乏 (中位数为16.3 ng/ml).
- 怀孕早期 (≤12周) 的缺陷风险增加了3.37倍.
- 早期缺乏与妊娠性甲状腺功能低下有关 (OR=1.32).
- 晚期缺陷矛盾地与较低的早产风险相关 (OR=0.32).
- 一个月后,维生素D3 (800 IU) 的含量比D2 (800 IU) 增加了25%以上的OH) D水平 (+28.4 vs +14.6 ng/ml).
结论:
- 维生素D缺乏症在德阳孕妇中很普遍,早期怀孕是高风险时期.
- 早期缺乏是甲状腺功能低下症的预测因素.
- 晚期缺乏和早产之间的反向关系需要进一步研究.
- 维生素D3是一种比D2更有效的补充剂.
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