泰国南部抗生素使用的气候决定因素:2021年至2023年间的回顾性纵向研究
Tanavij Pannoi1, Sukrit Sawangppon2, Wen-Chi Pan3
1School of Pharmacy, Walailak University, Nakhon Si Thammarat, Thailand.
Environmental epidemiology (Philadelphia, Pa.)
|February 9, 2026
概括
气候对泰国的抗生素使用有很大影响. 较低的温度增加了四环素的使用,而较高的温度和降雨增加了β-乳酸的处方,影响了抗菌药物管理.
科学领域:
- 环境科学 环境科学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素消费受到环境因素的影响,特别是在气候变化的热带地区.
- 气候变化可能会导致传染病和抗生素处方的季节性模式.
- 这项研究调查了泰国三级医院气候和抗生素使用之间的联系.
研究的目的:
- 为了检查气候变量 (温度,湿度,降雨) 和抗生素消费之间的关系.
- 了解环境因素如何影响特定类抗生素的使用.
- 以环境数据为抗微生物药物管理计划提供信息.
主要方法:
- 从2021年至2023年对7,696个抗生素处方 (四环素,β-乳糖胺,宏类) 的分析.
- 定义每日剂量 (DDDs) 的建模使用通用增剂和分布式滞后非线性模型.
- 评估与温度,湿度和降雨的相关性,包括延迟和非线性影响.
主要成果:
- 环素的使用在1月达到峰值,在温度下降≥2°C后增加45-60%.
- 随着气温上升和降雨量增加 (>100毫米/两周),β-乳的使用增加了20-30%.
- 在高湿度 (>80%) 的情况下,麦克罗利德的处方减少了高达25%,并且随着温度变化而波动.
结论:
- 气候因素对抗生素消费模式产生了特定类别的影响.
- 将环境监测整合到抗微生物药物管理中可以提高准备能力和资源分配.
- 建议进行多中心研究以验证发现并探索病原体特异性影响.
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