基于深度学习的病理学特征模型的构建和验证,用于预测患有清细胞细胞癌的患者的术后复发
Yiren Yang1, Jinxin Li1, Yisha Gao2
1Department of Urology, Changhai Hospital, Naval Medical University Shanghai, China.
American journal of cancer research
|February 9, 2026
概括
一个新的深度学习模型CRPNet准确地预测了手术后清细胞细胞癌 (ccRCC) 的复发. 这种先进的工具为ccRCC患者提供了改进的风险分层和预后,优于现有的方法.
科学领域:
- 在瘤学瘤学.
- 计算病理学计算病理学
- 人工智能在医学中的应用
背景情况:
- 清细胞细胞癌 (ccRCC) 在手术后复发是一个重大的临床挑战.
- 准确的ccRCC复发的早期预测对于及时干预和改善患者结果至关重要.
- 现有的预测工具往往缺乏有效风险分层所需的精度.
研究的目的:
- 开发和验证基于注意力的多实例深卷积神经网络 (CRPNet),用于ccRCC的早期术后复发预测.
- 评估CRPNet的预后性能与已建立的临床名录和工具相比.
- 评估CRPNet将ccRCC患者分为高风险和低风险组进行复发的能力.
主要方法:
- 开发CRPNet,一个基于注意力的多实例深度卷积神经网络.
- 培训和内部验证使用183名ccRCC患者和75名ccRCC患者的整体幻灯片图像 (WSI).
- 通过卡普兰-梅尔分析,AUC,准确度,精度,回忆,FPR/FNR,C指数和HR进行预测评估,与UISS,SSIGN和Karakiewicz名录相比较.
主要成果:
- 在预测ccRCC复发方面,CRPNet表现出卓越的表现,在培训和验证队列中实现了高AUC,准确性和精度.
- 通过CRPNet识别的高风险组在各种子组中显示出明显较差的预后 (P < 0.001).
- 在C指数和风险分层方面,CRPNet的表现优于传统的nomograms,具有更高的危险比率 (HR: 12.078).
结论:
- 与传统的预后模型相比,CRPNet为预测ccRCC复发提供了更高的准确性和优越的风险分层.
- 该模型为转移性ccRCC提供了更好的预后,具有较低的假阳性和假阴性率.
- 在ccRCC管理中,CRPNet代表了用于精密瘤学的计算病理学的重大进步.
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