相关实验视频
Updated: Feb 10, 2026

04:20
Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
Published on: February 9, 2024
1.5K
TMEM121通过与ERK通路的相互作用抑制宫癌细胞的增殖和迁移
Haochen Wang1, Siting Xu1, Sihui Li2
1College of Life Sciences, Hunan Normal University Changsha 410081, Hunan, China.
American journal of cancer research
|February 9, 2026
概括
跨膜蛋白121 (TMEM121) 通过与ERK相互作用,抑制子宫癌的生长,降低p-ERK1/2水平. 这种相互作用为宫癌提供了新的治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 宫癌仍然是一个重大的全球健康挑战.
- 在包括子宫癌在内的各种癌症中,MAPK信号通路经常失调.
- 了解调节癌症进展的新型分子机制对于开发有效疗法至关重要.
研究的目的:
- 研究跨膜蛋白121 (TMEM121) 在宫癌中的作用.
- 阐明涉及TMEM121在宫癌中的分子相互作用和信号通路.
- 探索TMEM121作为宫癌治疗点的潜力.
主要方法:
- 对公开可用的数据库进行生物信息分析.
- 使用AlphaFold3.3进行蛋白相互作用预测.
- 实验验证包括共免疫沉和免疫光.
- 通过RNA测序和流细胞计分析.
主要成果:
- 在宫癌组织中,TMEM121表达与ERK表达有负相关.
- TMEM121与ERK1/2直接相互作用,导致p-ERK1/2.2的下调.
- 全长的TMEM121及其跨膜域都抑制了宫癌细胞的增殖和入侵.
- TMEM121的过度表达会诱导S阶段细胞周期停止,这种情况通过ERK抑制剂是可逆的.
结论:
- TMEM121通过与ERK的相互作用和随后的MAPK信号通路的调制来抑制宫癌细胞的生长,增殖和入侵.
- TMEM121的跨膜域对其瘤抑制功能至关重要.
- TMEM121代表了一个有前途的新目标,用于开发宫癌的诊断和治疗策略.
相关概念视频
Cancer Cell Migration through Invadopodia
3.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.3K
Interactions Between Signaling Pathways
7.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.4K
Cell Migration
6.7K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.7K
Cell Migration
18.8K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.8K
Cells Coordinate Growth and Proliferation
5.1K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.1K
C4 Pathway and CAM
49.3K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
C4 Pathway
The C4 pathway is used by plants such as...
49.3K

