与香烟烟雾相比,加热烟草产品的气溶排放:一个范围审查
Stefano Bellosta1, Alberto Corsini1, Gabriele Catena2
1Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Università degli Studi di Milano, via Balzaretti 9, Milan 20133, Italy.
Toxicology reports
|February 9, 2026
概括
与传统香烟相比,加热烟草制品 (HTP) 的毒素含量显著降低,有害活动减少. 虽然HTP使用者接触的次数较少,但长期健康影响需要进一步调查.
科学领域:
- 烟草减少伤害研究研究
- 毒理学和公共卫生问题
- 对产品进行比较分析.
背景情况:
- 加热烟草制品 (HTP) 被销售为可燃烟草香烟 (TC) 的不那么有害的替代品.
- 关于HTPs实际减少有毒物质暴露和潜在的健康益处存在不确定性.
- 需要临床前和临床证据来验证HTP降低风险的说法.
研究的目的:
- 系统地评估临床前和临床研究,比较HTP和TC之间的有毒物质暴露和危害生物标志物.
- 评估转换到HTPs所带来的有毒物质减少程度和潜在的健康益处.
- 发现当前关于使用HTP对健康的长期影响的研究中的差距.
主要方法:
- 在PubMed (2017年1月至2024年10月) 的系统文献搜索中,发现了1105篇文章.
- 对符合纳入标准的43篇文章进行了分析,以分析气溶成分,毒理学和生物标志物数据.
- 干预性临床研究按暴露时间 (急性到长期) 分类.
主要成果:
- 与TC烟相比,HTP气溶含有高达95%的受监管毒素,并显示有害活动减少了85-95%.
- 在24项临床研究中,有20项报告称,在专用HTP使用者中,毒性暴露生物标志物 (BOE) 减少了40-97%.
- 在不同持续时间内观察到BoE的减少,并且在很大程度上独立于尼古丁水平,尽管四项研究没有发现任何改善或不良影响.
结论:
- 与可燃烟草相比,HTP使用与显著降低毒素暴露和减少有害活动有关.
- 虽然国际卫生当局承认HTP气溶中成分度较低,但潜在的风险尚未得到证实.
- 进一步独立的长期研究是必要的,以确定持续使用HTP对健康的最终影响.
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