在关键人群中,乙型肝炎的护理级联到全球消除:系统性审查和元分析
Shu Su1, Meng Jia1, Qingxian Song1
1Department of Epidemiology and Biostatistics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
The Lancet regional health. Western Pacific
|February 9, 2026
概括
乙型肝炎病毒 (HBV) 护理级联数据对于关键人群来说不足,在不同群体中进行了低于最佳的疫苗接种和查. 艾滋病毒感染者 (PLHIV) 显示出强烈的治疗坚持,但在实现HBV消除目标方面总体存在差距.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 关键人群不成比例地受到乙型肝炎病毒 (HBV) 的影响.
- 需要综合证据来实现世卫组织2030年HBV消除目标.
- 专注于脆弱群体内的HBV护理级联.
研究的目的:
- 在关键人群中系统地审查和元分析HBV护理级联指标.
- 为了确定不同群体和地区的HBV护理的差距和差异.
- 为实现全球HBV消除目标的战略提供信息.
主要方法:
- 观察性研究 (2019-2025) 的系统审查和元分析.
- 搜索了PubMed,科学网,奥维德和Embase的关于艾滋病毒感染者 (PLHIV),与男性发生性关系的男性 (MSM),女性性工作者 (FSW),吸毒者 (DU) 和被拘留者的研究.
- 分析了HBV护理级联指标,包括疫苗接种,查,与护理的联系,治疗,坚持,阳性,病毒抑制和功能治愈,使用通用线性混合模型.
主要成果:
- 包括来自329项研究的693个数据点,揭示了关键人群中HBV护理级联的大量变化.
- PLHIV显示了全级别估计,治疗覆盖率高 (88.9%) 和坚持 (86.1%),但疫苗接种率低 (16.3%).
- 在MSM中,疫苗接种率高 (48.0%),但查率低 (59.9%);在FSW中,疫苗接种率低 (10.3%) 和阳性率高 (7.1%);在DU中,功能治愈率高 (15.4%);在被拘留者中,疫苗接种率低 (25.6%). 观察到显著的区域差异,尽管负担最大,但非洲的覆盖率最低.
结论:
- 对大多数关键人群存在不充分的HBV护理级联数据.
- 在所有研究的群体中,疫苗接种和查仍然低于最佳水平.
- 有针对性的干预措施对于解决护理差距和实现2030年HBV消除目标至关重要.
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