携带多药耐药细菌和编码基因的越南儿童急性腹
Xuan Duong Tran1,2,3, Thi Loi Dao3, Ndiaw Goumballa1,2
1Aix Marseille Univ, AP-HM, SSA, RITMES, Marseille, France.
IJID regions
|February 9, 2026
概括
多药耐药细菌和耐药基因在急性腹的儿童中很常见,这表明先前的暴露. 这凸显了需要更好的抗微生物药物管理和感染控制,以对抗日益增长的耐药性.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 遗传学 是一个遗传学.
背景情况:
- 越来越多的多药耐药 (MDR) 细菌的流行率构成了全球健康的重大威胁.
- 儿童,特别是那些因急性腹住院的儿童,是携带MDR生物体的脆弱人群.
研究的目的:
- 确定患有MDR细菌携带者和在急性腹住院的幼儿中特定耐药性编码基因的患病率.
- 为了调查这些孩子的便样本中是否存在胆固醇抗性基因.
主要方法:
- 一项前性研究涉及451名因急性腹住院的5岁以下儿童.
- 便样本分析用于MDR细菌识别,抗微生物敏感性测试和耐药基因实时PCR (包括胆固醇抗性基因).
主要成果:
- 33.2%的儿童携带MDR细菌和/或胆固醇抗性基因.
- 在17.6%的儿童中发现了MDR病原体,常见的分离物包括大肠杆菌,金黄色葡萄球菌和Klebsiella pneumoniae.
- 对常见抗生素观察到高耐药率,并且经常检测到特定的耐药基因 (例如,mecA,blaCTX-M-A,mcr-1).
结论:
- 在患有急性腹的儿童入院时,经常检测到MDR细菌载体和耐药基因.
- 结果表明社区或先前的医疗保健暴露,而不是在医院的选择.
- 迫切需要加强抗微生物药物管理,感染控制和诊断,以应对这一公共卫生挑战.
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