产前暴露于新兴农药和儿童过敏风险:城市出生队列中的混合评估
Sergio Gómez-Olarte1, Stefan Röder1, Michael Borte2
1Department of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig 04318, Germany.
概括
产前接触农药与儿童喘和喘息有关. 这项针对德国城市儿童的研究发现,特定的农药和混合物增加了过敏风险,突出了需要进一步研究的需要.
科学领域:
- 环境健康 环境健康
- 儿科过敏 儿科过敏
- 毒理学 毒理学 毒理学
背景情况:
- 关于城市环境中产前接触农药和儿童过敏的证据有限.
- 在怀孕期间接触农药可能会影响儿童过敏疾病的发展.
研究的目的:
- 研究6岁时对单个和混合农药的产前暴露与过敏结果 (喘,喘息,湿疹) 之间的关联.
- 确定在德国城市出生队列中导致过敏疾病的特定农药和混合物.
主要方法:
- 通过非向查,对387名怀孕妇女的尿样进行40种农药和代谢物的LiNA队列分析.
- 应用多变量逻辑回归和加权量素总和 (WQS) 回归来评估在6岁时农药暴露和过敏结果之间的关联.
主要成果:
- 在二基-甲和儿童喘 (aOR=1.35) 和fluazifop-desbuthyl和喘息 (aOR=1.14) 之间发现了显著的关联.
- WQS回归表明,较高的农药共同暴露显著增加了喘息的几率 (aOR=2.08),其中fluazifop-desbuthyl,flonicamid,hydroxy-metazachlor和terbuthylazine是主要的贡献者.
- 对于湿疹没有观察到任何显著的关联.
结论:
- 产前接触农药,可能来自饮食来源,与儿童喘和喘息风险增加有关.
- 研究结果表明,特定的农药及其混合物有助于过敏性疾病的发展.
- 需要进一步的研究,包括复制研究和机制验证,以证实这些关联.
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